硝酸甘油型实验性偏头痛大鼠模型颈总动脉血流动力学初探  

Hemodynamic changes study of common carotid artery in migraine rat model induced by glyceryl trinitrate

作　　者：章正祥[1] 曹克刚[2] 范吉平[3] 

机构地区：[1]浙江省中医院神经内科,杭州310006 [2]北京中医药大学东直门医院神经内科 [3]中国中医科学院

出　　处：《浙江医学》2013年第1期26-28,共3页Zhejiang Medical Journal

基　　金：国家自然科学基金资助项目（30600828）

摘　　要：目的观察硝酸甘油（GTN）偏头痛大鼠模型颈总动脉血流动力变化。方法采用皮下注射GTN法建立偏头痛大鼠模型。应用CBI脉冲多普勒血流计、BIOPAC多导生理信号记录仪对空白组、生理盐水组、硝酸甘油组血压稳定10min后连续6h监测血流动力变化，运用NOTOCORD—Hem3．5系统提取1、2、3、4、5、6h等时间点的血流速度、心率、收缩压、舒张压、平均动脉压。结果GTN皮下注射后1h及2h血流速度分别降低（-8．35±3．41）cm／s和（-7．84±3．90）cm／s，而1、2、4h硝酸甘油组血流速度变化率与生理盐水组和空白组相比均下降（P〈0．05）。GTNSC后收缩压变化率、舒张压变化率、平均动脉压变化率在1、2、4h三个时间点与生理盐水组和空白组相比均降低（均P〈0．05）。结论GTN致偏头痛模型大鼠颈总动脉血流速度持续下降，为进一步研究该模型提供实验依据。Objective To study hemodynamic changes of common carotid artery in migraine rat model induced by glyc- eryl trinitrate （GTN）. Methods Migraine rat model was established with GTN （10mg/kg,sc）. Hemodynamic changes of blank group, normal saline group and GTN group after stable blood pressure for 10 minutes were monitored continuously by CBI pulsed Doppler flowmeter and BIOPAC multiplying channel physiological signal recorder for 6 hours, blood flow velocity, heart rate, sys- tolic blood pressure, diastolic blood pressure and mean arterial pressure were extracted at 1,2,3,4,5,6 hours with NOTOCORD - Hem 3.5 soft system. Results Blood flow velocity descended （-8.35 ± 3.41）cm/s and（-7.84 ± 3.90）cm/s after lh and 2h of GTN sc, At lh, 2h, 4h blood flow velocity change rate had decreased compared with normal saline group and blank group （P〈0.05）. Systolic blood pressure change Rate, diastolic blood pressure change rate and mean arterial blood pressure change rate in GTN group were lower more than normal saline group and blank group in the three time points of lh, 2h, 4h （P〈0.05）. Conclusion B^ood flow velocity of common carotid artery has continued to decline induced by GTN for the further study of migraine rat model provides experimental evidence.

关 键 词：硝酸甘油 血流动力学 偏头痛 

分 类 号：R285.2[医药卫生—中药学]