心型脂肪酸结合蛋白在急性心肌梗死6h内的诊断价值  

Diagnostic value of heart-type fatty acid-binding protein in acute myocardial infarction within six hours

作　　者：刘甲兴[1] 杨聪德[1] 黄勉君[1] 蔡智伟[1] 

机构地区：[1]解放军第180医院心内科,福建泉州362000

出　　处：《临床军医杂志》2013年第2期114-115,共2页Clinical Journal of Medical Officers

摘　　要：目的探讨心型脂肪酸结合蛋白(H-FABP)在急性心肌梗死(AMI)发病6 h内的诊断价值。方法将48例发病6 h内入院的AMI患者作为研究组,50例冠脉造影正常者入选对照组。采用双抗体夹心ELISA法定量检测血清H-FABP和肌钙蛋白(cTnⅠ)值,分别绘制两指标在AMI发病6 h内的特征曲线(ROC),比较曲线下面积(AUC)。并按推荐CUTOFF值计算敏感性、特异性。结果 6 h内H-FABP和cTnⅠ比较,AUC、敏感性差异有统计学意义(P<0.01)。结论 H-FABP用于AMI发病6 h内诊断的准确度高于cTnⅠ。Objective To evaluate the diagnostic efficacy and value of heart-type fatty acid-binding protein （H-FABP） in acute myocardial infarction （AMI） within six hours. Methods Forty-eight patients hospitalized within six hours after the onset of chest pain and determined as AMI were enrolled in trial group. Another 50 healthy subjects with normal coronary angiogram （CAG） were enrolled in control group. H-FABP and troponins Ⅰ （ eTn Ⅰ ） concentrations of the two groups were measured by sandwich ELISA, and the receiver operating characteristics （ROC） curves for diagnosing AMI within six hours were drawn. The areas under the curve （AUC） were calculated. Sensitivity and specificity were calculated and compared using CUTOFF test. Results AUC and sensitivity of H-FABP within six hours were much higher than that of cTn Ⅰ （ P 〈 0.01 ）. Conclusion H-FABP is effective for early diagnosis of AMI. Within six hours, it has a much higher accuracy than cTn Ⅰ.

关 键 词：心肌梗死 脂肪酸结合蛋白 生化标志物 

分 类 号：R542.22[医药卫生—心血管疾病]