不同肉桂与黄连配伍比例对交泰丸中肉桂酸含量的影响  

Influence on content of cinnamic acid in Jiaotai bolus with different compatibility ratio of Cortex Cinnamomi and Rhizoma Coptidis

作　　者：陈广[1] 陆付耳[2] 徐丽君[2] 邹欣[2] 王开富[2] 董慧[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院中西医结合科,湖北武汉430030 [2]华中科技大学同济医学院附属同济医院中西医结合研究所,湖北武汉430030

出　　处：《中国医院药学杂志》2013年第4期267-269,共3页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金资助课题(编号:30801492)

摘　　要：目的:探讨肉桂与黄连不同配伍比例对交泰丸中肉桂酸溶出率的影响。方法:各配伍组中药采取水煎法,色谱柱:XTerra RP18(4.6 mm×250 mm,5μm);流动相:甲醇-乙腈-水-四氢呋喃-(15∶15∶65∶5),冰醋酸调pH值为5.0;流速:0.8mL·min-1;检测波长:270 nm;柱温:室温;进样量:10μL。结果:肉桂∶黄连=1∶2、肉桂∶黄连=1∶4与肉桂单煎剂肉桂酸溶出率差异明显,且随黄连比例提高,肉桂酸溶出率随之减少。结论:黄连对肉桂有效成分肉桂酸的溶出有抑制作用。OBJECTIVE To explore the influence on dissolvability of cinnamic acid of Cortex Cinnamomi and Rhizoma Coptidis decoction with different compatibility. METHODS All the drugs were decocted and condensed. XTerra RP18 （4. 6 mm× 250 mm, 5 μm） was employed with mobile phase of methanol-acetonitrile-wateFtetrahydrofuran （15 ： 15：65：5） with pH = 5.0 adjusted with glacial acetic acid, the flow rate was 0. 8 mL.min^-1 and UV detection wave length was 270 nm in room tempera ture, RESULTS Significant difference was detected on dissoluability of cinnamic acid between Cortex Cinnamomi ： Rhizoma Coptidis = 1 ： 2, Cortex Cinnamomi： Rhizoma Coptidis = 1 ： 4 decoction and Cortex Cinnamomi. And cinnamic acid dissolvability decreased when the Rhizoma Coptidis content increased in formula. CONCLUSION Rhizoma coptidis with high dosage administration in jiaotai bolus could lead to decreased dissolvability of cinnamic acid.

关 键 词：肉桂 黄连 肉桂酸 溶出率 高效液相色谱 

分 类 号：R96[医药卫生—药理学]