厄贝沙坦与氨氯地平治疗2型糖尿病合并高血压的临床研究  

The clinical study of irbesartan and amlodipine for the treatment of type 2 diabetes combined with hypertension

作　　者：魏兆丽[1] 高爱滨[1] 崔玉英[1] 

机构地区：[1]滨州市中心医院内分泌科,山东滨州251700

出　　处：《中国临床药理学杂志》2013年第2期86-88,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价厄贝沙坦和氨氯地平2种药物单独应用及联合应用3种降压方案对2型糖尿病合并高血压患者的疗效与安全性。方法 116例2型糖尿病合并高血压患者随机分为3组:厄贝沙坦组(A组)37例,氨氯地平组(B组)38例,厄贝沙坦+氨氯地平组(C组)41例,均持续治疗8周,治疗前后分别测定静息状态下血压、体重指数(BMI)、空腹血糖(FPG)、空腹胰岛素(FINS)、C反应蛋白(CRP)、尿微量白蛋白(MALB)。结果 3组患者在治疗8周后收缩压和舒张压均明显降低。3组患者在治疗后胰岛素抵抗水平指标(HOMA-IR)均有减轻。C组患者治疗后CRP水平稍有降低,而A组和B组患者无显著变化。A组和C组患者尿MALB治疗后较治疗前有降低,而B组无明显改善。结论厄贝沙坦联合氨氯地平治疗2型糖尿病合并高血压的临床效果优于单独用药,其血压达标率明显提高,可改善胰岛素敏感性、降低CRP和减轻肾功能损害。Objective To investigate the effect of irbesartan and amlo- dipine, irbesartan or amlodipine in patients of type 2 diabetes mellitus combined with hypertension. Methods One hundred and sixteen patients with type 2 diabetes combined with hypertension were randomly divided into three treatment groups： group A （group irbesartan, n = 37）, group B （group amlodipine, n = 38 ）, group C （irbesartan and amlodipine, n = 41 ）. Each group were treated for 8 weeks. Blood pressure, insulin sensitivity , C -reaction protein and the level of microalbmninuria were evaluated before and after treatment. Results Both systolic and diastolic blood pressure were decreased significantly among all groups after treatment. HOMA - IR index was significantly decreased in three groups. C - reaction protein was decreased after treatment in group C, but there was no difference in group A and group B. Mieroalbuminuria in group A and group C were significantly decreased after treatment, but there was no difference in group B. Conclusion Compared to irbesartan or amlodipine, combined irbesartan and amlodipine had a better management for patients with type 2 diabetes mellitus combined with hypertension and significantly increased the controlled rate of blood pressure, offered an advantage due to its improvement of insulin sensitivity, decreasing C -reaction protein and renal dysfunction.

关 键 词：2型糖尿病 高血压 厄贝沙坦 氨氯地平 

分 类 号：R972.4[医药卫生—药品] R544.1[医药卫生—药学]