多次静脉滴注头孢拉宗钠在中国健康受试者血清的杀菌活性  

Serum bactericidal activity of cefbuperazone sodium in multi-dose intravenous of multiple in healthy subjects of China

作　　者：韩宇扬[1] 梁蓓蓓[2] 白艳[2] 裴广胜[2] 王科平 蔡芸[2] 白楠[2] 张志华[1,4] 王睿[2] 

机构地区：[1]河北北方学院研究生部,河北张家口075000 [2]中国人民解放军总医院药物临床研究中心,北京100853 [3]张家口市传染病医院检验科,河北张家口075000 [4]河北北方学院附属第一医院呼吸科,河北张家口075000

出　　处：《中国临床药理学杂志》2013年第2期109-111,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价多次静脉滴注头孢拉宗钠在中国健康受试者血清的杀菌活性。方法 12名健康受试者,男女各半,连续静脉滴注头孢拉宗钠,每次1 g,q12 h,连续7 d。给药后1 h(峰时)和12 h(谷时)分别采血,用微量稀释法测定血清杀菌活性(SBA)。结果头孢拉宗钠对产超广谱β内酰胺酶(ESBLs)的肺炎克雷伯菌(K.pneumonia)和大肠埃希菌(E.coli)峰时SBA≥1:8百分率为93%和86%,谷时SBA≥1∶1百分率为60%和90%。对甲氧西林敏感的金黄色葡萄球菌(MSSA)峰时血清抑菌活性(SBS)≥1∶2为81%,峰时SBA≥1:2百分率仅达42%,谷时SBA≥1:1百分率为0。结论头孢拉宗钠对产ESBLs的K.pneumonia和E.coli显示了很强的体内杀菌效果,而对MSSA体内峰时抑菌作用尚可,但杀菌作用较差。Objective To evaluate the in vivo antibacterial activity of cefbuperazone sodium. Methods Twelve healthy volunteers were given introvenous cefbuperazone sodium, 1 g every 12 hours for 7 days. After daily administration 1 h （peak concentration） and 12 h （valley concentration） respectively, blood samples were collected . Serum bactericidal activity （SBA）were determined by microdilution. Results The SBA percent that cefbuperazone sodium against Klebsiella pneumoniae and Escherichia coli producing ESBLs of peak exceed 1 ： 8 were 93% ,86% and valley exceed 1：1 were 60% , 90%. The percent of serum bacteriostatic ac- tivituy （SBS） and SBA that cefbuperazone sodium against MSSA of peak exceed 1：2 were 81% and 42% ,valley of SBA exceed 1：1 was 0. Conclusion Cefbuperazone sodium have shown very powerful similar results to producting ESBLs Klebsiella pneumonia and Escherichia coli of SBS and SBA . Effect on MSSA of bacteriostatic action was general but bactericidal action was relatively poor.

关 键 词：头孢拉宗钠 超广谱Β内酰胺酶 血清 杀菌活性 

分 类 号：R978.11[医药卫生—药品]