加巴喷丁治疗颈椎术后轴性症状的临床疗效评价  

The clinical effect of the gabapentin on the axial symptom after cervical operations

作　　者：桑裴铭[1,2] 张明[2] 陈斌辉[2] 蔡畅[3] 顾仕荣[1] 裘成莉[2] 

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]宁波市医疗中心李惠利医院骨二科,浙江宁波315040 [3]宁波市医疗中心李惠利医院麻醉科,浙江宁波315040

出　　处：《中国临床药理学杂志》2013年第2期124-125,共2页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价加巴喷丁胶囊在治疗颈椎术后轴性症状(AS)的临床疗效。方法颈椎术后出现轴性症状的100例患者,随机分组,A组(50例)口服加巴喷丁胶囊;B组(50例)口服塞来昔布胶囊,随访8周,用视觉模拟评分方法(VAS)观察治疗轴性症状的临床疗效。结果患者治疗后1,4,8周与治疗前VAS评分比较,2组内差异有统计学意义(P<0.05);治疗后1,4周VAS评分,2组间差异有统计学意义(P<0.05)。在治愈时间与不良反应上,2组间差异有统计学意义(P<0.05)。结论加巴喷丁胶囊在治疗颈椎术后轴状症状中具有良好的效果,并且不良反应少。Objective To investigate the clinical effect of the gabapentin capsule on the axial symptom after cervical operations. Methods After cervical operations, one hundred patients who had the axial symptom were randomly divided into group A and group B, fifty patients in each group. Group A took the gabapentin capsule and fifty patients in group B took the celecoxib capsule till the symptom disappeared and totally have been followed up for 8 weeks. The axial symptoms were assessed through the VAS score. Results Compared to pretreatment, the patients＇ symptom were improved after taking the gabapentin or celecoxib capsule for a week（P 〈 0. 05）. There were significant differences between the two groups after a week and four weeks treatment （ P 〈 0. 05 ）. There were significant differences in the time of taking medicine and in the ratio of complications（P 〈 0. 05）. Conclusion It is the worthy of the clinical application using the gabapentin capsule to treat the axial symptom after cervical operations.

关 键 词：颈椎病 轴性症状 加巴喷丁 

分 类 号：R971.6[医药卫生—药品] R687.3[医药卫生—药学]