64例别嘌醇引起皮肤系统损害分析  

Analysis of 64 Cases Adverse Skin Reactions Caused by Allopurinol

作　　者：叶晓兰[1] 石大伟[1] 汤从容[1] 杨方红[1] 张秀华[1] 

机构地区：[1]温州医学院附属第一医院药剂科,浙江温州325000

出　　处：《药物流行病学杂志》2013年第2期64-66,共3页Chinese Journal of Pharmacoepidemiology

基　　金：浙江省康恩贝医院管理软件项目(编号:2009AZHA-211)

摘　　要：目的:探讨别嘌醇引起皮肤系统不良反应的表现及发生规律,为临床安全用药提供参考。方法:我院不良反应监测系统2005年1月～2012年3月使用别嘌醇引起的皮肤系统不良反应病例进行统计分析。结果:共检索到ADR 64例,以中老年居多(51例,79.7%),其常用日剂量为50～100 mg(51例,79.7%),潜伏期2 d～4个月不等;皮肤系统ADR的临床表现以一般型、剥脱性皮炎型及多形红斑型的药疹为主,占73.4%,60%患者有伴随症状。结论:临床应重视别嘌醇皮肤系统不良反应的危害性。对老年患者更应注意密切观察用药后反应,确保用药安全。Objective： To study the expressions and rules of adverse drug reactions induced by allopurinol and provide references for rational clinical drug use. Methods：Adverse reaction cases of allopurinol were collected from the Ad- verse Reaction Monitoring Center of Wenzhou Medical College from January 2005 to March 2012, and the manifestation in skin damage, analyzed. Results：The adverse reactions occurred more easily to the middle-aged and old men（ 51 cases, 79.7% ） in the 64 eases, and the latent period was 2-95d. The skin damages were mainly presented as common types, drug-induced epidermolysis, drug-induced exfolialive dermatitise which took up a total of 73.4%, and 60%. The patients had some accompanying symptoms. Conclusion：Importance should be attached to the skin damage induced by allopurinol. Reactions should be closely observed to eflsure the safety of dru~ use. esneciallv for elderly patients after treatment.

关 键 词：别嘌醇 药品不良反应 皮肤系统 皮疹 痛风 

分 类 号：R983.2[医药卫生—药品]