空心莲子草抗病毒有效物质部位的化学成分研究  

Study the Chemical Constituents of Antiviral Effective Material Parts of the Alternanthera philoxeroides(Mart.) Griseb.

作　　者：王金波[1,2] 王佳馨[1] 陈树和[1,2] 刘焱文[1] 

机构地区：[1]湖北中医药大学中药资源与中药复方省部共建教育部重点实验室,湖北武汉430061 [2]湖北省中医院,湖北武汉430061

出　　处：《中国现代中药》2013年第2期88-92,共5页Modern Chinese Medicine

基　　金：国家自然科学基金(30470194)

摘　　要：目的:研究空心莲子草抗病毒有效物质部位正丁醇萃取物的化学成分。方法:采用溶剂法和色谱法对该植物的正丁醇部位进行提取分离,通过波谱分析与文献对照鉴定化合物的结构。结果:从中分离并鉴定了8个化合物,分别为竹节参苷Ⅳa(chikusetsusaponin-Ⅳa,1)、28-β-D-吡喃葡萄糖氧基-28-酮基-30-降齐墩果-12,20(29)-二烯-3β-O-β-D-吡喃葡萄糖醛酸(28-β-D-glucopyranosyloxy-28-oxo-30-noroleana-12,20(29)-dien-3β-O-β-D-glucopyranosiduronicacid,2)、竹节参苷Ⅳa甲酯(chikusetsusaponinⅣamethylester,3)、28-β-D-吡喃葡萄糖氧基-28-酮基-30-降齐墩果-12,20(29)-二烯-3β-O-β-D-吡喃葡萄糖醛酸甲酯(28-β-D-glucopyranosyloxy-28-oxo-30-noroleana-12,20(29)-dien-3β-O-β-D-glucopyranosiduronicacidmethylester,4)、大豆苷(daidzin,5)、芒柄花苷(ononin,6)、3-O-β-D-吡喃葡萄糖基齐墩果酸-28-O-β-D-吡喃葡萄糖苷(3-O-β-D-glucopyranosyloleanolicacid-28-O-β-D-glucoside,7)、28-β-D-吡喃葡萄糖氧基-28-酮基-30-降齐墩果-12,20(29)-二烯-3β-O-β-D-吡喃葡萄糖(28-β-D-glucopyranosyloxy-28-oxo-30-noroleana-12,20(29)-dien-3β-O-β-D-glucopyranoside,8)。结论:化合物5～8为首次从空心莲子草和莲子草属植物中分离得到。Objective：Sepatation of antiviral effective chemical constituents by n-butanol extraction from Alternanthera philoxeroides（Mart.）Griseb.. Methods： Dissolvent method and chromatograply method were used to extract and isolate n-butanol extracts of this plant, spectroscopic analysis and literature comparison method were used to identify structure of compounds. Results： 8 compounds were obtained and identified. These are chikusetsusaponin-Ⅳa（1）,28-β-D-glucopyranosyloxy-28-oxo-30-noroleana-12,20（29）-dien-3β-O-β-D-glucopyranosiduronic acid（2）,chikusetsusaponin Ⅳ a methyl ester（3）,28-β-D-glucopyranosyloxy-28-oxo-30-noroleana-12,20（29）-dien-3β-O-β-D-glucopyranosiduronic acid methyl ester（4）,daidzin（5）,ononin（6）,3-O-β-D-glucopyranosy oleanolic acid-28-O-β-D-glucoside（7）,28-β-D-glucopyranosyloxy-28-oxo-30-noroleana-12,20（29）-dien-3β-O-β-D-glucopyranoside（8）.Conclusion： Among these compounds, the 5～8 compound were reported in first time from Alternanthera philoxeroides plants.

关 键 词：空心莲子草 抗病毒 化学成分 结构鉴定 

分 类 号：R285.5[医药卫生—中药学]