附子不同炮制方法比较分析  

Comparative Analysis of Different Processing Methods in Aconiti Lateralis

作　　者：周林[1,2] 任玉珍[1] 杜杰[1] 张晓莉 金锋[4] 

机构地区：[1]中国药材公司中药质量控制技术国家工程实验室,北京100195 [2]北京中医药大学中药学院,北京100102 [3]四川江油中坝附子科技发展有限公司,四川江油621700 [4]河南中医学院,河南郑州450008

出　　处：《中国现代中药》2013年第2期135-139,共5页Modern Chinese Medicine

基　　金：中医药行业科研专项--附子等中药炮制方法传承与规范化应用研究项目(201107008)

摘　　要：目的:采用高效液相色谱法分析附子不同炮制品中6个生物碱的含量,研究《中国药典》炮制法、蒸制法、炒制法之间的差异。方法:采用《中国药典》2010年版附子含量测定项下方法检测;运用SPSS17.0统计分析软件进行数据处理。结果:各成分分离良好;蒸附片、炒附片、黑顺片、白附片、淡附片、炮附片中双酯型生物碱的量都得到有效降低,但蒸附片和炒附片中单酯型生物碱的含量明显增加。结论:蒸制法、炒制法与《中国药典》炮制法一样,具有相同的炮制减毒能力,但蒸制法和炒制法又能增加毒性小、疗效好的单酯型生物碱类的量,优于《中国药典》炮制法。Objective： By simultaneous quantification of 6 aconitum alkaloid compounds in Aconiti Laterahs to compare the differences from the different processing methods. Methods： The method of aconitum alkloids in Aconiti Lateralis is according to Chinese Pharmacopoeia （2010 ed） . Data is carried out by SPSS 17.0 statistical analysis software. Results： The 6 compounds were separated clearly. The amount of diester-type aconitum alkaloid compounds have been effectively reduced by pharmacopoeia method, steamed method and frying method, but the monoester-type aconitum alkaloid content in zhengfupian and chaofupian was significantly increased. Conclusion： Pharmacopoeia method, steamed method and frying method have the same processing attenuated ability. The contents of monoester-type aconitum alkaloid, which had low toxicity and high curative effect, are increased greatly in using the last two methods, better than the pharmacopoeia method.

关 键 词：附子 炮制 高效液相色谱法 含量比较 

分 类 号：R283.3[医药卫生—中药学]