硫酸依替米星治疗细菌性感染临床评价  

Efficacy and safty of etimicin sulfate in the treatment of bacterial infections

作　　者：吕晓菊[1] 杨尧[1] 王琳[1] 裘雁秋[1] 周志强[1] 陈德宇[2] 徐亮[2] 张竟修 黄永茂[2] 赵和平 刘守阳 徐忠能 杨宏涛 

机构地区：[1]华西医科大学附属第一医院,成都610041 [2]泸州医学院附属医院,泸州646000 [3]昆明军区总医院,昆明650000

出　　处：《中国抗生素杂志》2000年第B05期14-18,共5页Chinese Journal of Antibiotics

摘　　要：采用非盲法多中心平行开放试验研究硫酸依替米星治疗急性细菌性感染的安全性及有效性。用药方案为每次 10 0～ 15 0 mg,静脉滴注 qd或 q12 h,疗程 7～ 10 d,共完成合格病例 134例 ,其中 111例细菌培养阳性 (82 .84% )。结果显示 :对 134例不同感染病种患者的临床有效率为 90 .2 9% ,对 111例不同细菌感染患者的临床有效率及细菌清除率均为 90 .0 9% ,不良反应发生率为 6 .72 % ,反应程度轻微。纸片药敏试验结果显示细菌对依替米星的敏感率与奈替米星相似 ,高于庆大霉素 (P<0 .0 5 )。结论 :硫酸依替米星是一个安全有效的治疗急性细菌性感染的抗菌药物。The efficacy and safty of etimicin sulfate were evaluated through an open parallelled, multicenter study. One hundrund and thirty four patients enrolled in the trial, and received etimicin sulfate 100~150mg introvenous drop qd or q12h for 7~10 days. Among 134 patients, 111 were bacteriologically evaluable (82.48%). All patients were included in the safty analysis. The efficacy rate of different kinds infections was 90.29%, and that of different bacterial infections was 90.09%, Bacterial clearance rate was 90.09%. Disk diffusion susceptibility results showed that the sensitivity rate of bacteria to etimicin was similar to that to netilmicin, higher than that to gentamicin (P<0.05). Nine suffered adverse events (6.72%). All adverse events were of mild severity. The data suggested that etimicin sulfate is effective and generally well tolerated in the treatment of acute bacterial infections.

关 键 词：硫酸依替米星 细菌性感染 多中心开放平行试验 

分 类 号：R978.12[医药卫生—药品] R515.05[医药卫生—药学]