纤维连接蛋白诊断心肌梗死的死后稳定性研究  

Study on the postmortem stabiliity of fibronectin for the diagnosis of myocardial infarction

作　　者：胡丙杰[1] 陈玉川[1] 祝家镇[1] 毕启明[1] 曾家乐 李杰 

机构地区：[1]中山医科大学法医学系,广州510089 [2]广东东莞市公安局法医室,东莞511700

出　　处：《中国法医学杂志》2000年第B06期7-9,共3页Chinese Journal of Forensic Medicine

基　　金：卫生部科研基金(96-1-127);卫生部优秀青年科技人才专项科研基金(97012);广东省自然科学基金(980078);广东省医药卫生青年科学研究基金(B1998013);广东省"五个一科教兴医工程"基金;中山医科大学211工程"基金

摘　　要：建立狗急性心肌缺血模型,应用免疫组织化学和图像分析技术,对用纤维连接蛋白诊断心肌梗死的稳定性进行研究。心肌缺血组织随死后放置时间延长,纤维连接蛋白阳性反应面积逐渐减少,但放置4周仍呈阳性反应;而正常心肌组织放置不同时间,均未见阳性反应。纤维连接蛋白在心肌梗死死后诊断上具有很好的稳定性,在法医学实践中具有重要实用价值。Experimental acute myocardial ischemia model of dog was established, and the postmortem stability of fibronectin for the diagnosis of mycardial infarction was studied with immunohistochemistry and image analysis technique. The results showed that the positive reaction areas of fibronectin in ischemic myocardial tissues decreased along with the prolongation of postmortem interval, but positive reaction of fibronectin could still be found in ischemic myocardia kept for 4 weeks postmortem. No positive reaction for fibronectin could be found in normal myocardia when kept for different times. So fibronectin is a quite stable marker for the postmortem diagnosis of myocardial infarction, and is of practical value in the forensic practice.

关 键 词：心肌梗死 纤维连接蛋白 免疫组织化学 

分 类 号：D919[医药卫生—法医学] [政治法律—法学] D