儿童病毒性脑炎124例临床及病毒病原学分析  

Clinical and viral etiology analysis of viral encephalitis in children:on 124 cases report

作　　者：吕有道 

机构地区：[1]四川省达州市中心医院儿科,635000

出　　处：《临床合理用药杂志》2013年第7期49-50,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的分析不同年龄段病毒性脑炎患儿的临床表现及脑脊液(CSF)病毒病原学特点。方法选取124例病毒性脑炎患儿,据年龄分为A组(<3岁)52例、B组(3～6岁)26例、C组(>6岁)46例。分析不同年龄段患儿的临床表现特点;应用多重引物聚合酶链式反应(PCR)方法对CSF进行病毒病原学检测,包括肠道病毒(EV)和疱疹病毒(HSV)I、II型及EB病毒(EBV)、巨细胞病毒(CMV),分析各病毒的季节与年龄分布的特点。结果 3组患儿均有发热、嗜睡、烦躁、淡漠等症状;A、B组伴有惊厥48例(61.5%),C组伴头痛44例(95.7%)。CSF病毒病原学检测阳性者78例(62.9%),其中以EV为主[36例(46.2%)],其次为HSV-Ⅱ型[18例(23.1%)],HSV-Ⅰ型未检出,CMV及EBV主要分布于4～9月;B组患儿病原检出率最高(76.9%)。结论 (1)除发热、嗜睡外不同年龄段病毒性脑炎患儿伴随症状不同;(2)应用多重引物PCR方法早期检测CSF病毒病原阳性率较高。Objective To analysis the clinical and cerebrospinal fluid（CSF） viral etiology characteristics of children viral encephalitis in different age. Methods Selected 124 cases children with viral encephalitis and divided into A group（ 〈 3 years） 52 cases, B group（3 ～ 6 years） 26 cases, C group（ 〉 6 years） 46 cases according to the age. Analyzed the clinical characteristics of different age groups; Detected the CSF for viral etiology using multiple primer polymerase chain reaction （PCR） method, including intestinal virus （ EV ）, herpes simplex virus （ HSV ） I , II, EB virus （ EBV ）, cytomegalovirus （ CMV）, analyzed the season and age distribution characteristics of each virus. Results Children in 3 groups had fever, lethar- gy, irritability, apathy and other symptoms ;48 cases patients （61.5%） accompanied with convulsions in A, B groups ,44 cases patients （95.7%） accompanied with headache in C group. Positive people of CSF viral etiology detection was 78 cases （62. 9% ）, in which EV 36cases （46.2%）, HSV- Ⅱ 18 cases （ 23. 1% ）, HSV- I was not detected, the main distribution of CMV and EBV was 4 - 9 month ; Pathogen detection rate of B group was highest （76.9%）. Conclusion （1） In addition to fe- ver and lethargy, different age groups of has different symptoms in children with viral encephalitis; （2） Using multiple PCR method for early detection of CSF viral pathogen has a higher positive rate.

关 键 词：脑炎 病毒性 多重引物聚合酶链式反应法 病毒病原学 

分 类 号：R725.1[医药卫生—儿科]