松弛素对老年大鼠心血管保护作用的研究  

Research on the cardioprotective effect of relaxin on aged rats

作　　者：严雯[1] 冯敏[1,2] 廖完敏[1] 夏秦[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030 [2]华中科技大学同济医学院附属协和医院

出　　处：《内科急危重症杂志》2013年第1期42-43,共2页Journal of Critical Care In Internal Medicine

基　　金：高等学校博士学科点专项科研基金(新教师基金)(No:20100142120043)

摘　　要：目的:研究松弛素(relaxin,RLX)对老龄大鼠心血管的保护作用。方法:20月龄雄性大鼠30只,随机分为对照组、生理盐水组、RLX组各10只。16周后处死动物前插管测定心功能,应用图像分析系统测量不同组别大鼠心肌胶原纤维含量。结果:RLX组心功能较对照组及生理盐水组明显改善(P<0.05),天狼猩红染色示RLX组心肌胶原纤维含量较对照组及生理盐水组明显减少(P<0.05)。结论:RLX可逆转老年所致的大鼠心肌纤维化,为临床治疗老年心脏损伤提供了新思路。Objective： To investigate the cardioprotective effect of relaxin （RLX） on aged rats. Methods： 20 month male aged rats were allocated randomly into three groups： control group, saline group and RLX group, 10 for each group. Rats cardiac function was detected after 16 weeks, and collagen deposition was measured in different groups by the image analysis system. Results：The cardiac function significantly improved in RLX group than that in control group and saline group （ P 〈 0.05 ） , and collagen deposition decreased in RLX group than that in control group and saline group （ P 〈 0.05 ）. Conclusion ： RLX can reverse myocardial fibrosis in the aged rats, thus it provides a new idea for clinical treatment of heart injury.

关 键 词：老龄大鼠 松弛素 心肌纤维化 心功能 

分 类 号：R54[医药卫生—心血管疾病]