前庭终器损害前后瘘管刺激前庭诱发电位的观察  

Fistula stimulating vestibular evoked responses before and after the damage of the vestibular end organ

作　　者：郭毓卿[1] 王泉良[1] 朱惠珍[1] 

机构地区：[1]上海第二医科大学附属第九人民医院耳鼻咽喉科研究室,上海200011

出　　处：《中国耳鼻咽喉颅底外科杂志》2000年第2期100-103,I002,共4页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：卫生部可信基金;上海市高教基金资助项目!(930 0 5 )

摘　　要：目的　在以往工作的基础上 ,进一步证明瘘管刺激前庭诱发电位的应用价值。方法　 14只健康白色红目豚鼠分成用药组 (8只 )和正常对照组 (6只 )。用药组每天肌肉注射庆大霉素 2 30mg/kg ,持续 5d。记录两组动物的前庭诱发电位。结果　扫描电镜证实该组动物壶腹嵴、囊斑毛细胞出现不同程度病理改变 ,基底膜毛细胞形态正常 ,瘘管刺激前庭诱发电位测试 ,见该诱发电位P1～P4各波振幅明显下降 ,与正常对照组比较有显著差异 ,而听性脑干反应 (ABR)测试结果两组未见显著性改变。结论　瘘管刺激前庭诱发电位可以作为显示前庭系病变客观和直接的观察指标 。Objective To further explore the value of the technique of fistula stimulating vestibular evoked responses (FSVER). Methods Fourteen healthy guinea pigs were divided into two groups: the gentamicin group (8 animals) and the control group (6 animals). In the gentamicin group, the animals were given gentamicin (im) in a dosage of 230 mg/kg per day for 5 continuous days. FSVER was recorded for every animal before and after gentamicin administration. Results The scanning electronic microscope examination showed that the crests and maculae had a hair cell loss to various extents while the inner and outer hair cells in the basilar membrane remained morphologically normal. FSVER test showed that the responses of the gentamicin group, compared with the control group, had a statistically amplitude decrease. The ABR test showed no difference in the responses between the two groups. Conclusion FSVER can be regarded as an indicator of vestibular disfuction and has a value of localizing diagnosis.

关 键 词：前庭疾病 化学诱导 诱发电位 听性脑干反应 

分 类 号：R764.302[医药卫生—耳鼻咽喉科]