Shigella Strains Are Not Clones of Escherichia coli but Sister Species in the Genus Escherichia  

作　　者：Guanghong Zuo Zhao Xu Bailin Hao 

机构地区：[1]T-Life Research Center and Department of Physics,Fudan University

出　　处：《Genomics, Proteomics & Bioinformatics》2013年第1期61-65,共5页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National Basic Research Program of China (973 Project, Grant No. 2007CB814800 and2013CB834100);the Shanghai Leading Academic Discipline Project (Grant No. B111);the National Key Laboratory of Applied Surface Physics and the Department of Physics, Fu-dan University

摘　　要：Shigella species and Escherichia coli are closely related organisms. Early phenotyping experiments and several recent molecular studies put Shigella within the species E. coli. However, the whole-genome-based, alignment-free and parameter-free CVTree approach shows convincingly that four established Shigella species, Shigella boydii, Shigella sonnei, Shigella felxneri and Shigella dysenteriae, are distinct from E. coli strains, and form sister species to E. coli within the genus Esch- erichia. In view of the overall success and high resolution power of the CVTree approach, this result should be taken seriously. We hope that the present report may promote further in-depth study of the Shigella-E. coli relationship.Shigella species and Escherichia coli are closely related organisms. Early phenotyping experiments and several recent molecular studies put Shigella within the species E. coli. However, the whole-genome-based, alignment-free and parameter-free CVTree approach shows convincingly that four established Shigella species, Shigella boydii, Shigella sonnei, Shigella felxneri and Shigella dysenteriae, are distinct from E. coli strains, and form sister species to E. coli within the genus Esch- erichia. In view of the overall success and high resolution power of the CVTree approach, this result should be taken seriously. We hope that the present report may promote further in-depth study of the Shigella-E. coli relationship.

关 键 词：SHIGELLA Escherichia coli Prokaryote phylogeny andtaxonomy Composition vector CVTree 

分 类 号：Q93[生物学—微生物学]