改进Zagoumenny还原法制备二苯甲醇  

Preparation of benzhydrol by means of improved Zagoumenny reduction

作　　者：张珍明[1,2] 王丽萍[1] 李树安[2] 赵红博[1,2] 齐家娟[1,2] 邵栋[1,2] 

机构地区：[1]中国矿业大学环境与测绘学院,江苏徐州221116 [2]淮海工学院化学工程系,江苏连云港222005

出　　处：《兰州理工大学学报》2013年第1期54-57,共4页Journal of Lanzhou University of Technology

基　　金：江苏省高校科研成果产业化项目(JHB2011-60);江苏省六大人才高峰项目(2009年)的资助

摘　　要：Zagoumenny是经典的二苯甲醇制备反应,在氢氧化钾存在下,二苯甲酮和乙醇在高压釜中完成反应.以乙二醇代替乙醇,反应能在常压下进行,最佳反应条件为n二苯甲酮∶n乙二醇∶n氢氧化钾=1∶33.3∶2.6,反应温度为178℃,反应时间为3.5h,收率为92.8%.产物结构用熔点仪、元素分析仪、气-质联用仪、红外光谱仪和核磁共振仪进行表征.Zagoumenny reduction was a classical reaction for preparation of benzhydrol from benzophenone and ethyl alcohol in presence of potassium hydroxide in autoclave.An improved procedure was studied where the ethylene glycol was used instead of ethanol to carry out this reaction at atmospheric pressure.The optimal conditions were found as follows： the molar ratio of foregoing reactants were 1∶33.3∶2.6 and the reaction underwent at 178 ℃ for 3.5 h to give the benzhydrol with yield of 92.8%.The structure of resultant was characterized with melting point detector,elemental analyzer,GC-MS,IR and 1H NMR.

关 键 词：Zagoumenny还原法 二苯甲醇 改进 制备 

分 类 号：TQ463[化学工程—制药化工]