环境铅暴露健康风险评价三种PBPK模型的比较  

Comparison of Three PBPK Models Used in Environmental Health Risk Assessment for Lead

作　　者：李梅[1] 王齐[1] 陈建伟[1] 周宜开[1] 

机构地区：[1]华中科技大学同济医学院公共卫生学院,环境与健康教育部重点实验室(华中科技大学),湖北武汉430030

出　　处：《中国社会医学杂志》2013年第1期60-62,共3页Chinese Journal of Social Medicine

基　　金：环保公益性行业科研专项(201109058)

摘　　要：介绍了用于环境铅健康风险评价的3种基于生理学的药物动力学(physiologically based pharmacokinetic,PBPK)模型,即O’Flaherty模型、Leggett模型和IEUBK模型,并对3种模型的应用对象、应用范围、结构及准确性进行比较,从而筛选最佳模型。Models have been widely used for health risk assessment （HRA）. In order to find out the most appro- priate model for lead exposure, this article described three kinds of physiologically based pharmacokinetic （PBPK） models used for HRA for lead （i. e. O＇Flaherty model, Leggett model and the Integrated Exposure Uptake Biokinet- ic （IEUBK） Model for Lead）, and compares their target population, range of applications, structure and accuracy.

关 键 词：模型 铅 环境健康风险评价 

分 类 号：R12[医药卫生—环境卫生学]