星点设计-响应面法优选身痛逐瘀胶囊中药材的提取工艺  

Optimization of Extraction Technology of Chinese Medicinal Material from Shentong Zhuyu Capsules by Central Composite Design and Response Surface Methodology

作　　者：马丁[1] 阮洪生[1,2] 刘树民[1] 

机构地区：[1]黑龙江中医药大学中医药研究院,哈尔滨150040 [2]黑龙江八一农垦大学生命科学技术学院,黑龙江大庆163319

出　　处：《中国药房》2013年第11期993-995,共3页China Pharmacy

摘　　要：目的:优化身痛逐瘀胶囊中药材的提取工艺。方法:以乙醇浓度、料液比、提取时间为考察因素,以阿魏酸、甘草苷和羟基红花黄色素A含量总和为指标,采用星点设计-响应面法优选最佳提取工艺。结果:最佳工艺条件为乙醇浓度49%,料液比1:13.7(m/V),提取时间156min,在此最佳条件下,身痛逐瘀胶囊中阿魏酸、甘草苷和羟基红花黄色素A含量总和的预测值为88.21mg/g,与试验结果(87.69mg/g)吻合极好。结论:所选方法简便、合理,预测性较好。To optimize the extraction technology of Chinese medicinal material from Shentong zhuyu capsules. METHODS： The extraction technology was optimized by central composite design and response surface methodology with ethanol concentration, ratio of material to liquid and extraction time as factors using the contents of ferulic acid, liquiritin and hydroxysaf- flor yellow A as index. RESULTS： The optimum technology was as follows： ethanol concentration of 49%, liquid-material ratio of 1 ： 13.7 （m/V） and extraction time 156 min. The predicted value of the total content offerulic acid, liquiritin and hydroxysaffior yel- low A was 88.21 mg/g under this condition, which was in line with Results of trial（87.69 rag/g）. CONCLUSION： The method is simple, reasonable and highly predictive.

关 键 词：身痛逐瘀胶囊 星点设计-响应面法 提取工艺 

分 类 号：R283.65[医药卫生—中药学] R284.2[医药卫生—中医学]