IL-6与OPG/RANKL/RANK信号通路在风湿性关节炎发病机制中的作用  

Effect of IL-6 and OPG/RANKL/RANK signal pathway in the occurrence of rheumatoid arthritis

作　　者：李盛村[1] 鲍捷[1,2] 王国祥[1,2] 

机构地区：[1]苏州大学体育学院,江苏苏州215021 [2]苏州大学捷美生物医学工程仪器联合重点实验室

出　　处：《现代预防医学》2013年第5期933-935,共3页Modern Preventive Medicine

基　　金：江苏省2011年度普通高校研究生科研创新计划项目(CXZZ11_0069);2011年江苏省高校自然科学研究面上项目(11KJD320001)

摘　　要：风湿性关节炎是一种常见的慢性全身性炎性疾病,属于自身免疫性疾病。研究表明IL-6结合IL-6受体发挥生物学效应和风湿性关节炎密切相关。IL-6对风湿性关节炎中软骨退化和降解的影响,可能是通过调节OPG/RANKL/RANK信号通路实现的。IL-6可以直接刺激破骨细胞,也可以通过促进RANKL的表达而间接增强破骨细胞活性,继而对风湿性关节炎的发生发展产生重要影响。Rheumatoid arthritis is a kind of common chronic systemic inflammatory disease, belong to autoimmune disease. Studies have shown that IL-6 combined to IL-6 receptor produce the biological effects related to rheumatoid arthritis closely. Ef- fect of IL-6 on cartilage degradation and degradation in rheumatoid arthritis that may be worked by regulating the OPG/RAN- KL/RANK signal pathway. IL-6 can stimulate osteoclast directly, and through promoting the expression of RANKL to indirectly strengthen osteoclast activity, and then have an important impact on the development of rheumatoid arthritis. We review the re- lated research of IL-6 and OPG/RANKL/RANK signaling pathway with rheumatoid arthritis.

关 键 词：IL-6 风湿性关节炎 OPG/RANKL/RANK 信号通路 

分 类 号：R593.22[医药卫生—内科学]