蚊虫驱避剂新进展  

Advances in mosquito repellent

作　　者：向婧洁[1] 钟延强[1] 樊莉[1] 鲁莹[1] 

机构地区：[1]第二军医大学药学院药剂学教研室,上海200433

出　　处：《中国媒介生物学及控制杂志》2013年第1期79-82,共4页Chinese Journal of Vector Biology and Control

摘　　要：蚊虫是疟疾等烈性传染病的传播媒介,长期以来人们为了控制蚊虫的摄食行为和虫媒疾病的传播,不断开发出化学合成和植物源的驱避剂,但由于驱避剂安全性、广谱性和高效性有待提高,经典的驱避剂面临挑战;随着对昆虫嗅觉系统研究的发展和驱避剂作用机制相关研究的深入,近期发现嗅觉共受体激动剂VUAA1代表了一种全新的驱避机制,以其相比经典驱避剂独特的优势,为昆虫驱避剂提供了新的研究和发展方向,具有巨大的潜力和良好的应用前景,将成为蚊虫驱避剂研究领域新的热点。该文对驱避剂的发展和驱避机制的研究进展进行了综述。Various synthetic and plant-derived mosquito repellents have been developed over a long period to control the feeding behaviors of mosquito, which is the vector of fulminating infectious diseases including malaria. However, traditional repellents are facing challenges due to their adverse effects, narrow spectrum, and low effectiveness. Along with the progress in research on insect＇ s olfactory system and repellent mechanism, it was found recently that VUAA1, an agonist for olfactory co-receptor and capable of over-activating an insect＇ s olfactory receptor, shows promise for mosquito control. This paper aims to review the development of mosquito repellents and advances in research on repellent mechanism.

关 键 词：驱避剂 作用机制 避蚊胺 VUAA1 蚊虫控制 气味受体 

分 类 号：R384.1[医药卫生—医学寄生虫学]