全麻药物机制研究的几点新进展  

The research progress of general anesthetics on the brain function

作　　者：李肇端[1,2] 刘兴奎[2] 喻田[2] 

机构地区：[1]天津市南开医院麻醉科,300100 [2]遵义医学院附属医院麻醉科

出　　处：《国际麻醉学与复苏杂志》2013年第3期277-280,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：背景全身麻醉应用于临床已有160多年的历史，但麻醉药导致相应的行为改变如意识丧失、遗忘和镇痛的神经生理机制是什么，至今仍不清楚，尤其对于其中最具特征性的全麻意识消失，人们对其了解最为肤浅。目的综述全身麻醉药对离子通道和受体、各脑电活动的影响和脑功能的变化。内容全麻机制的研究可以分6个层次，分别是：分子水平、突触水平、细胞水平、神经微环路水平、系统水平（脑区）以及行为水平。总结近年来全身麻醉药（以下简称全麻药）在不同结构水平研究的最新进展，并从宏观上探讨全麻药对脑功能的影响。趋向多种实验技术相结合将为全麻机制的研究提供新的方法。Background The clinical application of general anesthesia has been used for more than 160 years, however, neurophysiological mechanism of corresponding behavioral changes caused by anesthetic such as loss of consciousness, amnesia and analgesic are still unclear, especially for the unconsciousness which we hardly understood. Objective We reviewed the impacts of general anesthetics on ion channels and corresonding receptors, as well as brain electrical activity and changes in brain functions. Content The research of general anesthesia mechanisms can be divided into six levels： the molecular, synaptic, cellular, neural micro-circuit, system （brain areas） and behavioral level. This review summarized the progress about general anesthetics on different levels and explored the change of brain functions by general anesthetics on macro level. Trend The combination of different kinds of experimental techniques could provide new approaches for general anesthesia mechanism.

关 键 词：全麻机制 受体 电生理 功能磁共振成像 

分 类 号：R614[医药卫生—麻醉学]