万通筋骨喷雾剂的体外经皮渗透效果考察  

Investigation of in vitro Transdermal Permeation Effect of Wantong Jingu Sprays

作　　者：葛克亚[1] 杜茂波[2] 刘淑芝[2] 李曼玲[2] 康琛[2] 宋立华[1] 王洪珍[3] 李颖[3] 

机构地区：[1]首都医科大学中医药学院,北京100069 [2]中国中医科学院中药研究所,北京100700 [3]通化万通药业股份有限公司,吉林通化134001

出　　处：《中国实验方剂学杂志》2013年第5期1-3,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家科技重大专项重大新药创制项目(2009ZX09301-005-05)

摘　　要：目的:考察万通筋骨喷雾剂的经皮渗透效果。方法:以绿原酸为指标,采用垂直式改良Franz扩散池装置进行试验,HPLC测定含量。结果:万通筋骨喷雾剂样品的透皮速率27.919μg.cm-2.h-1,6 h内平均累积透过率13.53%;绿原酸喷雾剂的透皮速率6.636μg.cm-2.h-1,6 h内平均累积透过率3.78%。结论:万通筋骨喷雾剂的体外透皮行为符合零级方程,其经皮渗透效果优于绿原酸喷雾剂。Objective：To investigate transdermal permeation effect of Wantong Jingu sprays. Method： Modified Franz diffusion cell was applied to investigate in vitro transdermal absorption behavior of Wantong Jingu sprays, with the content of chlorogenic acid as index,which was determined by HPLC. Result： In six hours,accumulated transdermal rate of Wantong Jingu sprays and chlorogenic acid sprays were 13.53%,3.78%,respectively; Transdermal rate were 27.919,6.636 μg·cm-2·h-1,respectively. Conclusion： In vitro transdermal absorption behavior of Wantong Jingu sprays was in accordence with zero-level equation,its transdermal absorption effect was better than chlorogenic acid sprays.

关 键 词：经皮渗透 绿原酸 高效液相色谱 喷雾剂 

分 类 号：R283.6[医药卫生—中药学]