三七总皂苷凝胶膏剂的体外渗透考察  

Investigation of in vitro Permeation of Panax notoginseng Total Saponins Gel Ointments

作　　者：吴静澜[1] 郭璐玫[1] 刘文[1] 

机构地区：[1]贵阳中医学院,贵阳550002

出　　处：《中国实验方剂学杂志》2013年第5期17-19,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：贵阳市科技计划项目(筑科合同2011201大-3号);贵阳中医学院研究生创新计划项目(ZYYCX11034号)

摘　　要：目的:考察三七总皂苷凝胶膏剂的体外渗透性,优选透过介质和渗透促进剂。方法:通过透皮扩散仪进行体外渗透试验,以三七皂苷R1,人参皂苷Rg1,人参皂苷Rb1含量为指标,研究三七总皂苷的体外渗透情况,采用HPLC检测三七总皂苷的透过量。结果:选用硝酸纤维素膜作为透过介质,1%氮酮为渗透促进剂时,渗透效果最佳;三七总皂苷凝胶膏剂24 h累积透过量683.97μg.cm-2,体外渗透符合Higuchi方程,渗透速率17.80μg.cm-2.min-1。结论:三七总皂苷凝胶膏剂具有较好的渗透性,适合作为三七总皂苷的新型透皮给药剂型。Objective：To investigate in vitro permeability of Panax notoginseng total saponins gel ointments,and optimize permeation medium and permeation enhancer. Method： With the total content of notoginsenoside R1,ginsenoside Rg1 and ginsenoside Rb1 as index,in vitro permeation of total saponins from P. notoginseng was detected by transdermal diffusion instrument,permeation amount of total saponins from P. notoginseng was determined by HPLC. Result： Penetration effect was the best with nitrocellulose membrane as permeation medium and azone as permeation enhancer;Accumulative permeation amount of P. notoginseng total saponins gel ointments in 24 h was 683.97 μg·cm-2,in vitro permeation could be described by model of Higuchi equation,and permeation rate was 17.80 μg·cm-2·min-1. Conclusion： P. notoginseng total saponins gel ointments had good permeability,it was suitable as a novel transdermal drug delivery formulation of total saponins from P. notoginseng.

关 键 词：体外渗透 氮酮 硝酸纤维素膜 透过量 

分 类 号：R283.6[医药卫生—中药学]