枸杞多糖对高脂血症大鼠血脂代谢及氧自由基的影响  

Effects of Lycium barbarum Polysaccharides on Lipid Metabolism and Oxygen Free Radicals in Hyperlipidemic Rats

作　　者：赵晶丽[1] 高红梅[2] 于海帅[1] 

机构地区：[1]吉林工业职业技术学院,吉林吉林132013 [2]长春中医药大学,长春130117

出　　处：《中国实验方剂学杂志》2013年第5期241-243,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨枸杞多糖(LBP)对高脂血症大鼠血脂代谢及氧自由基的影响。方法:健康雄性Wistar大鼠60只,按体重随机分为空白对照组、高脂血症模型组、LBP高、中、低剂量组和阳性对照组;除空白对照组,其余各组采用高脂饲料喂养法建立大鼠高脂血症模型;模型建立成功后,空白对照组和模型组ig给予蒸馏水,其余各组分别灌胃给予LBP(80,40,20 mg.kg-1)及辛伐他汀2 mg.kg-1。4周后,测定血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白(HDL-C)、超氧化物歧化酶(SOD)、丙二醛(MDA)及谷胱甘肽过氧化物酶(GSH-Px)水平。结果:与高脂血症模型组比较,LBP各剂量组大鼠血清TC,TG,LDL-C均显著下降(P<0.05或P<0.01),而HDL-C则显著升高(P<0.05);SOD,GSH-Px活性显著升高(P<0.05或P<0.01),而MDA水平显著下降(P<0.05或P<0.01)。结论:LBP能调节高脂血症大鼠血脂代谢水平,清除氧自由基,防止脂质过氧化,延缓动脉粥样硬化形成。Objective：To study the effects of Lycium barbarum polysaccharides （LBP） on lipid metabolism and oxygen free radicals in hyperlipidemic rats. Method： Sixty Wistar rats were randomly divided into six groups： normal control group, high-lipid model group, LBP high, medium and low-dose group and positive control group. The rat model of hyperlipidemic was established by high-fat diet feeding. After 4 weeks, the rats were given with LBP （80, 40, 20 mg·kg-1） and simvastatin 2 mg·kg-1. At the end of 4 weeks, the abdominal aortic blood was collected and determined total cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDL-C）, superoxide dismutase （SOD）, malondialdehyde （MDA） and glutathione peroxidase （GSH-Px）. Result： Compared with hyperlipidemia model group, serum TC, TG, LDL-C level in each treatment group decreased significantly （P〈0.05 or P〈0.01）, HDL-C significantly increased （P〈0.05）; SOD and GSH-Px activity significantly increased （P〈0.05 or P〈0.01）, MDA levels decreased significantly （P〈0.05 or P〈0.01）. Conclusion： LBP could adjust the level of lipid metabolism of rat model of hyperlipidemia, inhibit the damage from oxygen free radicals, prevent lipid peroxidation, and delay atherosclerotic formed.

关 键 词：枸杞多糖 高脂血症 血脂代谢 氧自由基 

分 类 号：R285.5[医药卫生—中药学]