降脂减肥胶囊治疗代谢综合征50例  

Effect of Jiangzhi Jianfei Capsule on 50 Patients of Metabolic Syndrome

作　　者：杨丽 徐静雯 杨树国 刘在松 郑杨 焦东海 

机构地区：[1]北京卫人中医医院中医减肥科,北京102200

出　　处：《中国实验方剂学杂志》2013年第5期300-303,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局中医药科学技术研究基金项目(国家中医药科02-03JP15)

摘　　要：目的:观察服用降脂减肥胶囊(大黄提取粉末等)加辨证中药汤剂配合腹部推摩治疗代谢综合征(MS)的疗效。方法:50例MS用辨证中药汤剂送服降脂减肥胶囊配合循经推摩治疗,疗程为1个月,观察对MS的疗效。结果:50例MS住院治疗1个月后对减肥全部有效,其显效率达82.9%,平均1个月减体重9.32 kg(相当于减去原体重的8.32%),腹围缩小11.86 cm(相当于减去原腹围的9.5%),减去体脂4.11 kg(相当于减去原体脂的10.2%),减水分2.28 kg(相当于减去多余水分的47%),体重指数(BMI)下降3.52。50例中43例高血压患者经1个月治疗后全部有效,其中37例降至正常(86.0%),24例血糖升高患者,18例降至正常水平(75%),1例无效(4%),50例中高血脂症42例有效36例,有效率为85.7%,其中16例降至正常(44%),4种类型的MS中对合并高血压的降压疗效最佳,但减体重最差。此前的动物实验与27例临床研究证明大黄提取粉不仅具有较好的减肥作用,同时能降低瘦素,改善机体胰岛素的抵抗状况,此作用与血清肿瘤坏死因子-α(TNF-α)浓度降低有关。结论:目前全世界尚缺乏一种有效的防治MS药物,因此如何在祖国医药中寻找出一种能防治MS的中药是研究的主要方向之一。Objective：To study effect of the Jiangzhi Jianfei Capsule on 50 cases of metabolic syndrome. Method： Fifty metabolic syndrom were recruited according to the national health organisis criteria. Each patient was administrated with refiined rhubarb powder 2-6 capsules bid for 4 weeks. Routin clinical assays： serum glucose,lipids,liver function and blood pressure were massured. Result and Conclusion： The capsule of powder extracted from rhubarb reduced the body weight, triglyceride, serum aspartate aminotrans ferase（AST）,alanine transaminase（ALT） uric acid and blood pressure were effective on the metabol 50 patients suffering from metabolic syndrome.The same time, the level of insulin, peptide C and tumor necrosis factor-α（TNF-α） remarkably lowered. There was a positive relationship between the serum insulin and TNF-α level.

关 键 词：代谢综合征 降脂减肥胶囊 高胰岛素血症 

分 类 号：R287[医药卫生—中药学]