肾脏细胞外基质降解的分子机制及中药的干预作用  

Molecular mechanisms of renal extracellular matrix degradation and interventional effects of Chinese herbal medicine

作　　者：魏晴雪[1] 万毅刚[2] 赵青[1] 陈好利[1] 孟宪杰[1] 姚建 

机构地区：[1]南京中医药大学中西医结合鼓楼临床医学院,江苏南京210029 [2]南京大学医学院附属鼓楼医院中医科,江苏南京210008 [3]Department of Molecular Signaling University of Yamanashi, Japan Yamanashi 409-3898

出　　处：《中国中药杂志》2013年第4期533-538,共6页China Journal of Chinese Materia Medica

基　　金：南京市卫生青年人才培养工程项目;江苏高校优势学科建设工程项目

摘　　要：肾脏细胞外基质(extracellular matrix,ECM)降解减少是慢性肾脏病(chronic kidney disease,CKD)肾组织损伤的形态特征和病理基础。在肾小球或肾间质中,ECM降解主要依赖于降解酶系统的调控,其中,基质金属蛋白酶(matrix metallo-proteinases,MMPs)发挥着核心作用。MMPs的表达和活性受控于"基因转录、酶原激活、特异性抑制剂"等经典途径。以尿毒清颗粒(Uremic Clearance granule)为代表的中药复方制剂及中药提取物可以干预ECM降解的多种途径,包括促进ECM成分降解、影响ECM降解酶表达、调节MMPs基因转录、抑制MMPs相关信号转导等。The reduction of extracellular matrix（ECM）degradation in kidney is taken as the morphological features and patho- logical base in renal injury in chronic kidney disease（CKD）. ECM degradation is controlled by the catabolic enzyme systems in glomerulus and renal interstitium, in which matrix metalloproteinases（MMPs） play a key role. The expression and activity of MMPs are regulated by the classical pathway, such as the genic transcription,the activation of zymogen,and the specific inhibitor. The previous studies showed that, Uremic Clearance granule,as a representation, and other prescriptions of Chinese herbal medicine,as well as some extracts from Chinese herbal medicine could intervene the pathway of ECM degradation through promoting the degradation of ECM components ,affecting the expression of catabolic enzymes, regulating the genetic transcription of MMPs, and inhibiting the relative signaling transduction of MMPs.

关 键 词：慢性肾脏病 细胞外基质 基质金属蛋白酶 中药 

分 类 号：R285[医药卫生—中药学]