基于健康相关生命质量结局的“肥胖矛盾”现象  

＂Obesity paradox＂--a phenomenon based upon the health-related outcome on quality of life

作　　者：朱燕波[1] 

机构地区：[1]北京中医药大学管理学院,100029

出　　处：《中华流行病学杂志》2013年第3期294-296,共3页Chinese Journal of Epidemiology

基　　金：国家重点基础研究发展规划“973”项目（2011CB505403）

摘　　要：BMI的增加已被确认是许多疾病的危险因素。但有大量研究显示，相对于BMI过低和正常的多种慢性疾病患者，其超重和肥胖的临床预后反而要好，即“肥胖矛盾”现象。关于BMI与健康相关生命质量（HRQoL）关系的研究显示，体质量的增加相关于中老年、慢性病人群较高的生命质量，慢性病HRQoL的减损更重要的不是肥胖的影响而是慢性病本身。由此提出这样的启示：是否肥胖者较高的HRQoL是较高生存率的潜在机制呢？The increase of body mass index （BMI） has already been recognized as one of the risk factors for many diseases. However, in patients with various diseases, data from large number of studies shows that when comparing with underweight and normal-weight patients, overweight and obesity have appeared better clinical prognosis, namely ＂obesity paradox＂. It has become one of the hot spots in domestic and foreign research areas of the sort. When studying the relationship between BMI and health-related quality of life （HRQoL） , we discovered that when BMI was increasing among the elderly or people with chronic diseases, it could predict a better quality of life among these populations. The impairment of HRQoL in chronic disease was not caused by the impact of obesity but by chronic diseases. These evidence triggered the idea that whether higher HRQoL of obesity was the potential mechanisms that leading to a higher survival rate？ It also provided a new entry point for searching possible mechanism in which related to the ＂obesity paradox＂ that raising new issues on reasonable weight management.

关 键 词：肥胖矛盾 体重指数 健康相关生命质量 

分 类 号：R589.2[医药卫生—内分泌]