热毒宁注射液治疗流行性感冒高热(热毒袭肺证)临床观察  

Clinical Observation of Reduning Injection in Treatment of Hyperpyrexia Caused by Influenza(Heat-toxin Attacking Lung Syndrome)

作　　者：孙航成[1] 张业清[1] 肖庆龄[1] 黄雅菊[1] 朱启勇[1] 

机构地区：[1]江苏省中西医结合医院呼吸科,江苏南京210028

出　　处：《辽宁中医药大学学报》2013年第3期179-181,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:验证热毒宁注射液治疗流行性感冒高热(热毒袭肺证)的疗效,并对其安全性作出客观评价。方法:采用随机、双盲双模拟、平行对照试验,观察流行性感冒高热(热毒袭肺证)患者共38例,其中试验组19例,对照组19例;用药方法:试验组用热毒宁注射液及磷酸奥司他韦胶囊模拟剂治疗,对照组用磷酸奥司他韦胶囊及热毒宁注射液模拟剂治疗。结果:两组在改善流行性感冒高热症状方面及改善中医证侯方面两组均有明显的疗效,二者间的差别无统计学意义。两组在退热起效时间及体温复常时间方面无显著性差异。临床观察中,无明显不良反应与严重不良事件。结论:热毒宁注射液治疗流行性感冒高热(热毒袭肺证)临床疗效确切,未发现明显毒副反应,与磷酸奥司他韦胶囊相仿。Objective ： To observe the effect of Reduning Injection on influenza, and evaluate its safety objectively. Methods ： It was designed to be a randomized, double-blind, parallel-group trial. 38 hyperpyrexia patients with influenza were randomly divided into the experimental group （ n=19 ） and the control group （ n=19 ）. In the experimental group, patients were treated by Reduning Injection and placebo （ appearance look like Osehamivir phosphate capsules ）, and in the control group, patients were treated by the Oseltamivir phosphate capsules and the placebo. Results ： The two groups both had significant effect on improving symptoms of hyperpyrexia caused by influenza and the syndromes of Traditional Chinese Medicine terms. There was no statistically significant difference between the two groups. There was no obvious difference in the part of antipyretic onset time and temperature recovery time. And no case was found with adverse reactions in the two groups. Conclusion ： Reduning Injection is effective for treating hyperpyrexia caused by influenza, and no adverse reaction has been observed, which is similar to Osehamivir phosphate capsules.

关 键 词：热毒宁注射液 磷酸奥司他韦胶囊 流行性感冒高热(热毒袭肺证) 双盲法 随机对照 

分 类 号：R254.9[医药卫生—中医内科学]