高强度聚焦超声治疗外阴上皮内非瘤样病变的随机对照研究  

Efficacy of high-intensity focused ultrasound in treatment of non-neoplastic epithelial disorders of vulva

作　　者：杨毅 王真[2] 史宏晖[2] 朱兰[2] 史欣文[2] 王涛[2] 陈娟[2] 王巍[2] 郎景和[2] 

机构地区：[1]北京市丰台妇幼保健院妇产科,北京100067 [2]中国医学科学院,北京协和医学院,北京协和医院妇产科,北京100730

出　　处：《生殖医学杂志》2013年第2期87-91,共5页Journal of Reproductive Medicine

基　　金：科技部十一五支撑项目(2008BAI57B06)

摘　　要：目的评价高强度聚焦超声(HIFU)治疗外阴上皮内非瘤样病变(NNEDV)的疗效与安全性。方法将59例经病理诊断为外阴上皮内非瘤样病变的患者随机分为HIFU组(n=29)和药物组(n=30),分别于治疗前、治疗后1个月和治疗后3个月进行症状、体征和生活质量评分和观察不良反应,比较两组患者的治疗效果和副反应。结果与治疗前相比,治疗后1个月和治疗后3个月两组患者症状和体征评分减少,生活质量评分增加,差异有显著性(P<0.05)。治疗后1个月,HIFU组患者疗效与药物组相比,治疗有效率有显著性差异(P<0.05),HIFU组患者的症状评分改善率与药物组相比,差异有显著性(P<0.05),而体征评分变化两组则无显著性差异(P>0.05)。治疗后3个月,HIFU组疗效与药物组相比,无显著差异(P>0.05),HIFU组未出现阴道周围组织损伤。结论 HIFU与药物治疗外阴上皮内非瘤样病变均具有良好的效果,与药物治疗相比,HIFU治疗具有显效快的特点,是外阴上皮内非瘤样病变治疗的安全有效途径之一。Objective： To evaluate the efficacy and safety of high-intensity focused ultrasound（HIP U）in treatment of non-neoplastic epithelial disorders of vulva. Methods： Fifty nine patients with non-neoplastic epithelial disorders of vulva diagnosed pathologically were randomly allocated to the high-intensity focused ultrasound（HIFU）group（29 patients）and cortical hormone group（30 patients）. Patients＇ signs and symptoms and the life quality and the adverse reaction were assessed before treatment, 1 month and 3 months after treatment respectively to evaluate the effect and side effect between the two groups. Results： Patients＇ signs and symptoms and life quality were improved in both groups after 1 month therapy. The patients＇ sign improvement in HIFU group significantly better than that in hormone group after 1 month treatment（P〈0.05）, while patients＇ symptoms in both groups was similar（P〉0.05）. Therapeutic effect had no significant difference between the two groups after 3 months treatment （P〉 0.05）. There was no paravaginal tissue injury in HIFU group. Conclusion： HIFU is one of the safe and effective methods in treatment of non-neoplastic epithelial disorders of vulva.

关 键 词：高强度聚焦超声 外阴上皮内非瘤样病变 临床疗效 

分 类 号：R71[医药卫生—妇产科学]