灵芝多组分微乳一步制备方法的探索  

Exploration of one-step preparation of Ganoderma lucidum multicomponent microemulsion

作　　者：贺俊杰[1,2] 陈彦[1,2] 杜萌[2] 曹伟[1] 袁菱[1] 郑丽燕[2] 

机构地区：[1]江苏省中医药研究院,国家中医药管理局中药释药系统重点研究室,江苏南京210028 [2]南京中医药大学附属中西医结合医院,江苏南京210046

出　　处：《药学学报》2013年第3期441-446,共6页Acta Pharmaceutica Sinica

基　　金：江苏省中医药领军人才项目(LJ200913)

摘　　要：灵芝为多孔菌科真菌赤芝Ganoderma lucidum（Leyss．ex Fr．）Karst．或紫芝Ganoderma sinense Zhao，Xu et Zhang的干燥子实体。最早记载于汉代《神农本草经》，具有滋补强壮、延年益寿、宁心安神、扶正固本之功效。现代研究表明灵芝具有较好的抗肿瘤作用，其中灵芝中含有的脂溶性三萜及水溶性多糖是灵芝抗肿瘤的主要有效组分。To explore one-step method for the preparation of Ganoderma lucidum multicomponent microemulsion, according to the dissolution characteristics of triterpenes and polysaccharides in Ganoderma lucidum, formulation of the microemulsion was optimized. The optimal blank microemulsion was used as a solvent to sonicate the Ganoderma lucidum powder to prepare the multicomponent microemulsion, besides, its physicochemical properties were compared with the microemulsion made by conventional method. The results showed that the multicomponent microemulsion was characterized as （43.32 ±6.82） nm in size, 0.173 ±0.025 in polydispersity index （PDI） and -（3.98±0.82） mV in zeta potential. The contents of Ganoderma lucidum triterpenes and polysaccharides were （5.95±0.32） and （7.58±0.44） mg＇mL-1, respectively. Sonicating Ganoderma lucidum powder by blank microemulsion could prepare the multicomponent microemulsion. Compared with the conventional method, this method is simple and low cost, which is suitable for industrial production.

关 键 词：灵芝 多组分 微乳 制备 

分 类 号：R943[医药卫生—药剂学]