多囊卵巢综合征患者抗苗勒氏管激素与相关临床指标的关系  

Relationship between Plasma Concentration of Anti-Müllerian Hormone (AMH) and Clinical Index in Women with Polycystic Ovary Syndrome

作　　者：徐燕颖[1] 尹利荣[1] 陈逢振[1] 王莉[1] 杨维娜[1] 

机构地区：[1]天津医科大学第二医院妇科,300211

出　　处：《天津医药》2013年第2期119-121,共3页Tianjin Medical Journal

基　　金：天津市卫生局科技基金(项目编号:2011KZ100)

摘　　要：目的探讨多囊卵巢综合征(PCOS)患者抗苗勒氏管激素(AMH)水平与体质指数(BMI)、激素及代谢指标的关系。方法将60例PCOS患者和30例不孕患者分为PCOS组1(BMI≥25kg/m2)、PCOS组2(BMI<25kg/m2),每组30例;对照组1(BMI≥25kg/m2)、对照组2(BMI<25kg/m2),每组15例。空腹采血并测定血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇、睾酮、血清AMH、空腹血糖和空腹血清胰岛素,计算稳态模型胰岛素抵抗指数(HOMA-IR),比较4组的上述指标并进行相关性分析。结果PCOS组AMH、LH、LH/FSH、睾酮、空腹胰岛素及HOMA-IR均高于对照组,PCOS组1和PCOS组2AMH差异无统计学意义,PCOS组1LH、LH/FSH低于PCOS组2,空腹胰岛素、HOMA-IR高于PCOS组2。PCOS组AMH与BMI无相关性。PCOS组1AMH与睾酮、空腹血糖、空腹胰岛素、HOMA-IR呈正相关,与雌二醇、FSH呈负相关;PCOS组2AMH与LH、LH/FSH、睾酮呈正相关(均P<0.05)。结论PCOS患者血清AMH显著升高,其升高与体质量无关,可能与激素紊乱和糖代谢紊乱有关。Objective To analyze interrelation between anti-Mullerian hormone （AMH） levels and body weight, hor- mone status and metabolic rate in women with polycystic ovary syndrome （PCOS）. Methods Sixty women （30 normal weight, PCOS 1 group and 30 overweight, PCOS 2 group） diagnosed as PCOS were enrolled and 30 healthy women （15 normal weight and 15 overweight non-PCOS） were as control group. The body weight and height were measured and body mass index（BMI） was calculated. The serum follicle-stimulating hormone （FSH）, luteinizing hormone （LH）, estradiol, testosterone, adrenal med- ullary hormone （AMH）, androgens, fasting glucose and fasting insulin were detected, and the homeostasis model of assess- ment-insulin resistance （HOMA-IR） were caculated and compared between four groups. Results The levels of AMH, LH, LH/FSH, testosterone, fasting insulin and HOMA-IR were higher in PCOS group than those of control group. There was no significant difference in AMH level between PCOS 1 and PCOS 2 groups. The levels of LH and LH/FSH were lower in PCOS 1 group than those of PCOS 2 group. The levels of fasting insulin and HOMA-IR were higher in PCOS 1 group than those of PCOS 2 group. There were no correlations in AMH and BMI levels in PCOS group. There were positive correlations in AMH and testosteronel fasting glucose and fasting insulin and HOMA-IR in PCOS 1 group, but a negative correlation between estra- diol and FSH. A significant positive correlation was found between LH, LH/FSH, testosterone and AMH in PCOS 2 group （P 〈 0.05）. Conclusion There is a significant increase in plasma AMH in patients with PCOS. The plasma AMH level is not as- sociated with BMI, which may have correlation with hormone imbalance and metabolic disorders.

关 键 词：多囊卵巢综合征 抗苗勒管激素 人体质量指数 促黄体激素 卵泡刺激素 睾酮 胰岛素 稳态模型胰 岛素抵抗指数 

分 类 号：R711.7[医药卫生—妇产科学]