乙型流感患者外周血白细胞和淋巴细胞亚群变化分析  

Changes and analysis of peripheral white blood cells and lymphocyte subsets for patients with influenza B virus infection

作　　者：徐震[1] 孙杰[1] 王家蔚[1] 吴烨[1] 郁峰[1] 

机构地区：[1]湖州市中心医院儿科,313000

出　　处：《中华实验和临床病毒学杂志》2013年第1期32-34,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的探讨乙型流感患者外周血白细胞和淋巴细胞亚群的变化特点，为乙型流感的诊断、治疗和预后判断提供实验室依据。方法采用全血细胞分析和流式细胞分析法分别检测47例乙型流感患者急性期和恢复期的外周血白细胞及淋巴细胞亚群，并与38名健康人比较。结果乙型流感轻症患者外周血白细胞总数在急性期显著下降，恢复期迅速上升，而重症患者外周血白细胞总数、中性粒细胞百分比及绝对值在急性期显著上升，恢复期迅速下降；所有乙型流感患者淋巴细胞总数、CD3、CD4、CD8、CD19在急性期显著下降，恢复期迅速上升；轻症患者的NK细胞绝对值在急性期与恢复期都与健康对照组无显著差异，而重症患者NK细胞绝对值在急性期显著下降，恢复期迅速上升。结论乙型流感患者在急性期出现白细胞总数及中性粒细胞的显著上升，而NK细胞绝对值的大幅降低可以提示病情重症化倾向。Objective To investigate the characters and changes of peripheral white blood cells and lymphocyte subsets of patients with influenza B virus infection and to provide evidences for diagnosis, treatment and prognosis of influenza B virus infection. Methods Peripheral white blood cell parameters and the percentages of lymphocyte subsets in acute and recovery phases of 47 cases of influenza B virus infection patients（ 32 mild cases and 15 severe cases）were investigated and analyzed, and Compared respectively with those of 38 cases of healthy people using whole blood cell analysis and flow cytometry. Results Peripheral white blood cell counts of mild cases decreased greatly but peripheral white blood cell counts and the neutrophils of severe cases increased significantly in acute phase; the peripheral lymphocytes, CD3, CD4, CD8 and CD19 of all patients with influenza B virus infection decreased greatly in acute phase and quickly recovered in recovery phase; there were similar characteristics of change in NK cells between patients with influenza B virus and healthy people. NK cells absolute counts of severe cases decreased significantly in acute phase. Conclusion Peripheral white blood cell counts and the neutrophils of increased significantly in acute phase and the great decrease of NK cells absolute counts of patients with influenza B virus infection may suggest the severe tendency of diseases.

关 键 词：流感病毒B型 血细胞计数 淋巴细胞亚群 

分 类 号：R511.7[医药卫生—内科学]