Sjgren综合征相关性干眼发病机制的研究进展  

Recent advances in pathogenesis research on Sjgren syndrome related dry eye

作　　者：魏瑞华 郝永娜[1,2] 边领斋 李雪[1,2] 粘红 赵少贞 

机构地区：[1]天津医科大学眼科医院 [2]天津医科大学眼视光学院,天津市300384

出　　处：《眼科新进展》2013年第3期286-289,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81100646);天津市科委自然科学基金资助(编号:11JCYBJC26000)~~

摘　　要：Sjgren综合征(Sjgren syndrome,SS)是一种主要累及外分泌腺、慢性炎症性的自身免疫性疾病,发病初期主要表现为泪液和唾液分泌减少所致的眼干、口干综合征,但在发病的晚期,会出现多系统损害的症状和体征。SS发病机制复杂,其确切发病机制国内外报道较少。目前,随着动物模型和实验检查技术的不断更新,关于SS发病机制的研究取得了新的进展,为早期诊断SS提供了新的理论证据。本文从遗传学、病理生理学方面就SS的发病机制做一综述,以期对SS相关性干眼的诊断和治疗有更新的认识。Sjogren syndrome （SS） is a chronic autoimmune disease that primarily affects the exocrinosity glands. In the earlier stage of the disease, SS is characterized by the dry eye, dry mouth syndrome, because of the decrease of tear and saliva secretion. However, in the later stage of the disease, there are signs and symptom of multisystemic damage. The pathogenesis of SS is complicated, and there is no fmding of the exact pathogenesis of this disease at home and abroad. At present, with the continuous renew- al of animal models and technology of experiment and examination, the study about the pathogenesis of SS obtains new advance, and provides new theory evidences for the ear- lier diagnosis of SS. This article reviews the pathogenesis of SS to more understand the diagnosis and treatment of SS related drv eve.

关 键 词：SJOGREN综合征 干眼 发病机制 

分 类 号：R442.8[医药卫生—诊断学]