度他雄胺治疗良性前列腺增生症的临床研究进展  

Research progress of dutasteride in men with benign prostatic hyperplasia

作　　者：穆鑫[1] 薛蔚[1] 

机构地区：[1]上海交通大学医学院附属仁济医院泌尿外科,上海200127

出　　处：《中国新药与临床杂志》2013年第2期97-100,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：度他雄胺是一种良好的治疗良性前列腺增生的药物,由于其疗效肯定、不良反应少等优点而备受关注。本文从度他雄胺抑制血清双氢睾酮水平、缩小前列腺体积、改善最大尿流率、降低IPSS评分、改善生活质量、降低急性尿潴留发生率、降低血前列腺特异抗原水平等方面的疗效及其存在的不良反应的方面介绍该药的研究进展,为该药的进一步研究及临床应用提供参考依据。Dutasteride is a good medicine in treating benign prostatic hyperplasia （BPH） . Because of positive clinical efficacy and less adverse reaction, it is getting obtained more and more attention. The efficacy and safety of dutasteride on suppression of serum DHT levels, reducing the prostate volume, improving themaximum flow rate, decreasing the IPSS score, improving quality of life, reducing the incidence of acute urinary retention, decreasing the serum PSA level and related adverse reactions are reviewed in this paper in order to provide reference frames for its further research and clinical application.

关 键 词：良性前列腺增生症 度他雄胺 临床研究 治疗 IPSS评分 不良反应 前列腺体积 最大尿流率 

分 类 号：R983[医药卫生—药品]