眼用制剂在家兔眼中的药动学研究进展  

Research progress in pharmacokinetics of ophthalmic preparations on rabbit eyes

作　　者：李健和[1] 易利丹[1] 曾小慧[1,2] 曹俊华[3] 左运叶[4] 彭六保[1] 

机构地区：[1]中南大学湘雅二医院药学部,湖南长沙410011 [2]中南大学药学院,湖南长沙410013 [3]湖南省马王堆医院,湖南长沙410016 [4]桂林医学院,广西桂林541000

出　　处：《中国新药与临床杂志》2013年第2期105-112,共8页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：眼科药动学主要研究眼对药物的吸收、分布、代谢和排出的规律,从而指导临床合理用药,提高疗效,减少不良反应。了解与眼科用药有关的药动学参数能有助于改进剂型,开发新制剂。本文对近年来眼用制剂在家兔眼中的药动学研究进展进行综述。Pharmacokinetics of ophthalmic preparations refer to the processes of drug absorption, distribution, metabolism and elimination in the eyes, aimed to guide clinical rational drug use, improve efficacy and reduce side effects. Detailed pharmacokinetic parameters can help improve the formulation, discover and develop new agents. This paper reviewed the pharmacokinetics of ophthalmic preparations on rabbit eyes in recent years.

关 键 词：眼用制剂 兔 药动学 合理用药 

分 类 号：R965[医药卫生—药理学] R969.1[医药卫生—药学]