递增式科氏加速度前庭习服训练的效果分析  

Investigation on Effects of Gradually Increased Coriolis Stimulus Vestibular Rehabilitation Training

作　　者：谈诚[1] 赵琦[1] 曹毅[1] 张丹[1] 牛东斌[1] 何思杨[1] 王林杰[1] 

机构地区：[1]中国航天员科研训练中心航天基础与应用国家重点实验室,北京100094

出　　处：《航天医学与医学工程》2013年第1期20-23,共4页Space Medicine & Medical Engineering

基　　金：973项目资助(2011CB711000);载人航天基础研究项目资助(01107002;SMFA11B02);国家自然科学基金项目资助(31070914)

摘　　要：目的观察递增式科里奥利(科氏)加速度刺激习服训练的效果并分析相关激素水平。方法 12名青年男性志愿者,按照首次训练运动病症状评分进行配对分组,共分为2组,分别进行连续4 d递增式科氏加速度刺激训练(A组:连续式科氏加速度每日刺激量分别为5,8,8和10 min,左右头动模式;B组:间断式科氏加速度每日刺激量分别为8,8,10和15 min,前后头动模式)。此外,所有志愿者在训练前1天和训练后1天,以及训练后1,2,3,5,9和14周分别进行前后头动和左右头动模式各2 min的科氏加速度刺激进行前庭功能的评定。以前庭刺激时的运动病症状评分和精氨酸加压素(arginine vaso-pressin,AVP)、皮质醇(cortisol,Cor)、肾素活性(renin activity,PRA)、血管紧张素(angiotensin,AII)和促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)的变化水平作为评价指标。结果训练后,志愿者运动病症状评分有明显降低,训练后2周显著低于检查前水平(P<0.05)。激素指标中,AVP含量在科氏刺激前后的变化百分比与运动病症状评分之间有显著的相关性(P<0.05),Cor,PRA,AII和ACTH在各时间点无明显差别。两种刺激模式的效果没有差异。结论 4 d的递增式前庭习服训练的效果至少可以维持至2周。AVP在前庭习服效应的构建和维持中可能扮演着重要的作用。Objective To investigate the effects of gradually increased Coriolis stimulus training on vestibular function and the levels of related hormones. Methods According to the motion sickness symptom score of the first vestibular test, 12 young male volunteers were divided into 2 groups. All of them were experienced a 4 d gradually increased vestibular training with different exercise protocol ： Group A （ continuous Coriolis stimulus ： 5, 8, 8, 10 min in each day, left-fight head movement, n = 6） ; Group B （intermittent Coriolis stimulus： 8, 8, 10, 15 rain in each day, fore-back head movement, n =6）. The vestibular function test, including a 2- min left-fight and 2-rain fore-back head movement, were examined on 1 d before training, on 1 day and on 1, 2, 3, 5, 9, 14 week （s） after training respectively. The evaluation consisted of motion sickness symptom score and changes of arginine vasopressin （AVP） , cortisol （Cor） , renin activity （ PRA ） , angiotensin （AII） , and adrenocorticotropic hormone（ACTH） in serum. Results The motion sickness symptom score on 1 day, and 1,2 weeks after training were significantly lower than those in pre-training （ P 〈 0.05 ）. And the AVP concentration changes had significant relationship with the motion sickness symptom score （P 〈 0.05 ）, but no in Cot, PRA, AII and ACTH. There was no significant difference between groups. Conclusion The effect of a 4 d continuous gradually increased Coriolis stimulus vestibular rehabilitation training could last approximately 2 weeks. AVP might play an important role in etiology of motion sickness and the mechanism of vestibular rehabilitation.

关 键 词：空间运动病 前庭习服 科氏加速度刺激 加压素 

分 类 号：R852.33[医药卫生—航空、航天与航海医学]