ficolins基因多态性与临床疾病易感性的研究进展  

Progress of genetic polymorphism in ficolins and disease susceptibility

作　　者：张涛[1] 周宏灏[1,2] 

机构地区：[1]重庆医科大学生命科学研究院,重庆400016 [2]中南大学临床药理研究所,湖南长沙410078

出　　处：《中国药理学与毒理学杂志》2013年第1期119-122,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81102511);重庆市自然科学基金(cstc2011jjA10004);中国博士后科学基金(2011M500669);重庆市博士后科研项目特别资助项目(渝xm201102007)~~

摘　　要：ficolins是天然免疫中的一种模式识别分子,最早被作为转化生长因子β1结合蛋白从猪子宫内膜中分离而来。ficolins与甘露聚糖结合植物凝集素功能相似,能结合病原微生物的糖类配基,通过补体途径和调理吞噬作用消灭病原体,在天然免疫中发挥重要作用。迄今为止,已发现M-ficolin,L-ficolin和H-ficolin 3种人类ficolin蛋白,分别由FCN1,FCN 2和FCN 3基因编码。随着研究的深入,越来越多的学者开始关注FCN基因多态性与疾病易感性之间的关系。大量研究发现,FCN基因多态性与疾病的易感性、严重性及疾病的发生发展密切相关。本文就FCN基因多态性与相关疾病易感性间的关系进行简述。Ficolins are pattern-recognition molecules, which were originally identified as transforming growth factor β1- binding proteins on porcine uterus membranes. The human ficolins, similar to the mannan-binding lectin, can bind to N- acetylglucosamine （GIcNAc） on the microbial cells and appear to be of major importance for innate immunity and tissue homeostasis. Three ficolin genes have been identified in humans： FCN1, FCN2 and FCN3, which encode M-ficolin, L-fi- colin and H-ficolin respectively. Recently, the role of the ficolins gene in disease has been emphasized. This review focu- ses on the recently discovered genetic polymorphism in FCN and the susceptibility of relative diseases.

关 键 词：FICOLINS 基因多态性 疾病易感性 

分 类 号：R392[医药卫生—免疫学]