Recent advances in the study of testicular nuclear receptor 4  

作　　者：Xian-fan DING Shi-cheng YU Bi-de CHEN Shin-jen LIN Chawnshang CHANG Gong-hui LI 

机构地区：[1]Department of Urology,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University [2]George Whipple Lab for Cancer Research,Departments of Pathology and Urology,University of Rochester

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2013年第3期171-177,共7页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Natural Science Foundation of China (No.30973001);the National Basic Research Program (973) of China (No.2012CB518304);the Zhejiang Provincial Natural Science Foundation of China (No.Y2110446);the Qianjiang Talents Project of Zhejiang Province (No.2011R10039);the PAO Yu-kong International Foundation for Scholars and Scientists,China

摘　　要：Testicular nuclear receptor 4(TR4),also known as NR2C2(nuclear receptor subfamily 2,group C,member 2),is a transcriptional factor and a member of the nuclear receptor family.TR4 was initially cloned from human and rat hypothalamus,prostate,and testes libraries.For almost two decades,its specific tissue distribution,genomic organization,and chromosomal assignment have been well investigated in humans and animals.However,it has been very difficult to study TR4's physiological functions due to a lack of specific ligands.Gene knock-out animal techniques provide an alternative approach for defining the biological functions of TR4.In vivo studies of TR4 gene knockout mice(TR4-/-) found that they display severe spinal curvature,subfertility,premature aging,and prostate prostatic intraepithelial neoplasia(PIN) development.Upstream modulators,downstream target gene regulation,feedback mechanisms,and differential modulation mediated by the recruitment of other nuclear receptors and coregulators have been identified in studies using the TR4-/-phenotype.With the establishment of a tissue-specific TR4-/-mouse model,research on TR4 will be more convenient in the future.Testicular nuclear receptor 4 （TR4）, also known as NR2C2 （nuclear receptor subfamily 2, group C, member 2）, is a transcriptional factor and a member of the nuclear receptor family. TR4 was initially cloned from human and rat hypothalamus, prostate, and testes libraries. For almost two decades, its spe- cific tissue distribution, genomic organization, and chromosomal assignment have been well investi. gated in humans and animals. However, it has been very difficult to study TR4＇s physiological functions due to a lack of specific ligands. Gene knock-out animal techniques provide an alternative approach for defining the biological functions of TR4. In vivo studies of TR4 gene knockout mice （TR4-/-） found that they display severe spinal curvature, subfertility, premature aging, and prostate prostatic intraepithe. lial neoplasia （PIN） development. Upstream modu- lators, downstream target gene regulation, feedback mechanisms, and differential modulation mediated by the recruitment of other nuclear receptors and coregu｜ators have been identified in studies using the TR4-^- phenotype. With the establishment of a tissue-specific TR4-/- mouse model, research on ＂I＇R4 will be more convenient in the future.

关 键 词：核受体 睾丸 前列腺癌 组织分布 动物技术 基因敲除 小鼠模型 染色体分配 

分 类 号：Q78[生物学—分子生物学] R346[医药卫生—基础医学]