5-羟色胺与骨质疏松症  

5-hydroxytryptamine and osteoporosis

作　　者：康庐琛[1,2] 邓伟民[1] 

机构地区：[1]广州军区广州总医院,广州5100101 [2]广州中医药大学,广州510405

出　　处：《中国骨质疏松杂志》2013年第2期185-190,共6页Chinese Journal of Osteoporosis

基　　金：军队中医药科研专项课题重点项目(10ZYZ115)

摘　　要：5羟色胺(5-Hydroxytryptamine,5-HT)是一种吲哚胺类化合物。根据其合成部位的不同,而分为外周性5-HT和中枢性5-HT,可以通过两种截然不同的、相反的途径调节骨量。5-HT相关系统已经展现出其作为新的治疗靶点和改善OP、影响骨代谢的巨大潜力,5-HT受体阻断剂、SERT拮抗剂等有望成为新的一类有效治疗骨质疏松症的良药。本文就外周性5-HT与骨质疏松症的研究进展作一综述。5-Hydroxytryptamine （5-HT） is a kind of indole amine compounds. According to different locations of synthesis 5-HT can be classified as peripheral 5-HT and central 5-HT, which can regulate the bone mass through two different and contrary pathways. 5-HT related system has showed tremendous potency in new treatment target, improving osteoporosis, and affecting bone metabolism. 5-HT receptor blockers and SERT antagonists are expected to be new drugs for the treatment of osteoporosis. This paper reviews the research progress of peripheral 5-HT and osteoporosis.

关 键 词：5羟色胺 骨质疏松 

分 类 号：R965[医药卫生—药理学]