恒河猴离乳幼猴B病毒动态监测  

Dynamic monitoring of B virus in the weanling infant rhesus macaques

作　　者：高进权[1] 佟巍[1] 张丽芳[1] 刘先菊[1] 王艳蓉[1] 向志光[1] 刘云波[1] 

机构地区：[1]中国医学科学院医学实验动物研究所北京协和医学院比较医学中心卫生部实验动物检测中心,北京100021

出　　处：《中国比较医学杂志》2013年第2期38-42,共5页Chinese Journal of Comparative Medicine

基　　金：国家科技支撑计划"实验动物质量保证条件和认可评价关键技术研究与示范"(2011BAI15B03);中央级公益性科研院所基本科研业务费专项资金项目(DWS201213)

摘　　要：目的调查恒河猴离乳幼猴BV感染的动态变化,探讨早期控制的可能。方法采用BV全病毒为抗原的ELISA试剂盒,对两批离乳后群养的54只恒河猴幼猴每月采血检测BV感染情况,连续检测13个月。结果随月龄的增加,BV感染率上升,其中12月、1月、2月、3月、4月BV阳性猴数量相对增加较明显。结论幼猴性成熟期之前BV感染率超过70%且呈现出一定的变化规律,春、冬季BV的感染率相对较高,应早期加强BV的有效预防控制,降低BV的感染,提高猴群质量。Objective Investigating dynamic changes of BV infection in the weanling infant rhesus monkeys to explore the possibility of early control. Methods A whole B virus-based ELISA kit was used to detect B virus antibodies of 54 weanling infant rhesus macaques every month for 13 consecutive months. Results With increasing month-old, BV infection rate rose and the number of B virus positive monkey was increased significantly in the period from December to April. Conclusions In the infant monkeys BV infection rate was over 70% before sexual maturity and showed some variation. It was apparently increased in spring and winter, suggest that effective prevention and control should be strengthened early, so as to reduce B virus infection and improve the monkeys quality.

关 键 词：B病毒 恒河猴 ELISA 阳性率 相对阳性率 

分 类 号：R33[医药卫生—人体生理学]