狼疮样肾炎小鼠模型研究进展  

Research progress of murine lupus nephritis models

作　　者：何艺磊[1] 杨林承[1] 李卫东[1] 

机构地区：[1]北京大学医学部基础医学院药理学系,北京100191

出　　处：《中国比较医学杂志》2013年第2期73-78,共6页Chinese Journal of Comparative Medicine

基　　金：北京市自然科学基金资助项目(No.7102100);国家自然科学基金资助项目(No.81173069);国家基础科学人才培养基金;J1030831/J0108

摘　　要：系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种以体内产生抗核抗体为特征的自身免疫性疾病,其病因目前未明,一般认为是遗传、环境、内分泌、感染等因素相互作用的结果。狼疮样肾炎小鼠模型与人SLE发病机制和病理变化等有着相似特点,是研究SLE、筛选抗炎免疫药物较理想的实验性病理模型。本文对近年来狼疮样肾炎小鼠模型制备的方法及评价进行了综述。Systemic lupus erythematosus （SLE） is characterized by the presence of anti-nuclear antibodies （ANA） directed against naked DNA and entire nucleosomes. Systemic lupus erythematosus is a multifactorial autoimmune disease affected by genetic, environmental, hormonal and infection factors. Murine model of lupus nephritis and its SLE pathogenesis and pathological changes have similar characteristics to that of SLE in humans. Therefore, murine SLE model is an ideal experimental pathological model for the study of SLE and screening of anti-inflammatory and anti-immune drugs. In this article, we will review the preparation methods and evaluations of murine models of lupus nephritis.

关 键 词：小鼠 狼疮样肾炎 模型 动物 

分 类 号：R33[医药卫生—人体生理学]