低氧训练中低氧诱导因子-1表达对骨骼肌铁代谢影响的研究进展  

Influence of Expression of HIF-1 in Hypoxic Training on Iron Metabolism of Skeletal Muscle

作　　者：杨杰[1] 李海洲[2] 

机构地区：[1]中国人民武装警察部队学院,河北廊坊065000 [2]廊坊师范学院,河北廊坊065000

出　　处：《廊坊师范学院学报（自然科学版）》2013年第1期89-93,共5页Journal of Langfang Normal University(Natural Science Edition)

摘　　要：铁在许多生理过程中发挥着重要的作用,参与机体ATP合成、氧的转运与利用。运动与铁代谢有着密切的联系,运动会改变机体铁稳态。低氧训练作为一种日益发展起来的训练方法对机体的运动能力产生较大的影响。低氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)作为低氧应答的关键环节使机体产生多方面适应性变化,近年来发现二价金属离子转运体1(divalent metal transporter l,DMT1)、EPO、跨膜丝氨酸蛋白酶6(transmenbrance serineproteases 6,TMPRSS6)等是HIF-1的靶基因,并深入影响了机体以及骨骼肌的铁代谢,有助于阐明低氧训练对骨骼肌铁代谢影响的机制。在低氧训练过程中肠铁吸收、机体铁状态的变化也会引起运动员骨骼肌铁代谢发生变化和适应性调节。Iron plays an important role in many physiological processes, such as ATP synthesis as well as oxygen trans-portation and utilization, exercise and iron metabolism have a close contact. Movement will change the stability of iron in our badys. Hypoxic training growing up as a training method on the body have a greater impact exercise capacity. Hy-poxic stimulation affect on iron transporter. HIF-1（hypoxia-inducible factor-1） is the key response to hypoxia which effect intestinal iron absorption and iron metabolism in skeletal muscle. In recent years, we found that divalent metal ion trans-porter 1, EPO, transmenbrance serine proteases 6 and so are the target genes of HIF-1. and further affect on the iron me-tabolism of body and skeletal muscle. While the changes of intestinal iron absorption and the body iron status of athletes are the reasons of the diversification of on metabolism of skeletal muscle under hypoxic training.

关 键 词：铁 低氧训练 骨骼肌 低氧诱导因子-1 

分 类 号：G804.2[文化科学—运动人体科学]