生物转化在黄酮类化合物中的研究与应用  

Research and application of biotransformation in flavonoids

作　　者：崔莉[1,2] 孙娥[1] 陈玲玲[1,2] 钱浅[1] 贾晓斌[1,2] 

机构地区：[1]江苏省中医药研究院中药制剂室,南京210028 [2]南京中医药大学,南京210046

出　　处：《中华中医药杂志》2013年第3期764-767,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金资助项目(No.30572372,No.30973944);江苏省医药高技术计划项目(No.BG2007614);江苏省科学技术项目(No.LZ09067)~~

摘　　要：黄酮类化合物具有广泛的药理活性,但是溶解度差、生物利用度低等弊端限制了其在临床上的广泛应用。而生物转化可以改变活性成分的结构,提高活性成分的溶解度和生物利用度,具有转化率高、无污染、能耗低等优点。随着生物科学的不断发展,生物转化逐渐应用于黄酮类化合物的研究中。文章介绍了生物转化中的去糖基化、羟基化、糖苷化、甲基化和成环反应等几种主要的反应类型,对生物转化在黄酮类化合物中的应用进行了综述。黄酮类化合物与生物转化技术的有机结合,必将为黄酮类化合物的资源开发推向新阶段,促进黄酮类化合物的新发展。Flavonoids had a wide range of pharmacological activity. However, the poorer solubility and lower bioavailability limited its widespread clinical application. It was very glad that biotransformation can change the structuresof active ingredients, whose solubility and bioavailability was improved. Biotransforrnation possessed the advantages of high conversion rate, no pollution, low energy consumption and so on. With the continuous development of biological sciences, biotransformation was gradually employed to study flavonoids. This article described several primary types of response, such as deglycosylation, hydroxylation, glycosylation, methylation and cyclization. The application of biotransformation in flavonoids was reviewed. And the combination of flavonoids and biological conversion technologies would push the resource development of flavonoids to a new shage, and promote flavonoids developing.

关 键 词：生物转化 黄酮类化合物 反应类型 应用 

分 类 号：R284[医药卫生—中药学]