乌司他丁联合丹参辅助治疗急性肺损伤的临床研究  

A clinical study on ulinastafin combined with salvia miltiorrhiza in adjuvant treatment of acute lung injury

作　　者：陈杰文[1] 林慧芯[1] 李抒玮[1] 

机构地区：[1]江门市中心医院,529070

出　　处：《国际医药卫生导报》2013年第3期322-324,共3页International Medicine and Health Guidance News

摘　　要：目的探讨乌司他丁联合丹参辅助治疗急性肺损伤的的临床效果及安全性。方法将100例急性肺损伤患者随机分为观察组和对照组，各50例。两组患者均给予常规治疗，观察组加用乌司他丁3000U／（kg·d）、丹参注射液30ml／d静脉注射。观察患者治疗前、后临床症状变化及治疗前、后血浆乳酸、超敏c反应蛋白0IS—CRP）含量、血浆肿瘤坏死因子-d（TNF-理）、白细胞介素-6（IL-6）水平和血气分析变化。治疗7d后观察疗效。结果观察组总有效率为92％，明显高于对照组的72％，差异有统计学意义（X2=_6．775，P〈0．01）。治疗前，两组患者血浆乳酸、hs—CRP、TNF-α、IL-6比较，差异无统计学意义（P〉0．05）；治疗后，观察组血浆乳酸、hs—CRP、TNF—d、IL_6显著低于对照组（P〈0．01）。治疗后，两组患者呼吸频率（RR）均明显下降，氧合指数（Pa02／FiO：）和动脉血氧分压（PaO2）显著上升，治疗前、后差异有统计学意义（P〈0．05），但治疗后观察组改善更显著（P〈0．05）。结论乌司他丁联合丹参辅助治疗急性肺损伤可以显著改善急性肺损伤患者预后，降低炎l生反应程度，缩短治疗时间，值得临床推广应用。Objective To explore the clinical efficacy and safety of ulinastatin combined with salvia miltiorrhiza in adjuvant treatment of acute lung injury. Methods 100 patients with acute lung injury were ran- domly divided into study group and control group, 50 for each group. Both groups received routine treatment. The study group received additional ulinastin of 3000 U/（ kg. d ） combined with salvia mihiorrhiza injection of 30 ml/d. Changes in symptoms, hs-CRP, lactate acid, TNF-cL , and IL-6 were observed. The efficacy was ana- lyzed 7 days after treatment. Results 7 days after treatment, the total effectiveness rate was significantly higher in the study group than in the control group （92% vs.72%, X 2 = 6.775, and P 〈 0.01 ）. Before treatment, plas- ma levels of hs-CRP, lactate acid, TNF- α, and IL-6 did not differ significantly （ P 〉 0.05 ）.7 days after treat- ment, levels of hs-CRP, lactate acid, TNF- α , and IL-6 were significantly lower in the study group （ P 〈 0.01 ）. The respiratory rate dropped sharply while Pa02 and Pa02/Fi02 were dramatically elevated in both groups after treatment （ P〈 0.05 ）, with a more obvious change in the study group. The respiratory rate, Pa02, and Pa02Fi02 were improved better in the study group （P〈 0.01 ）. Conclusions Ulinastatin combined with salvia miltiorrhiza injection in the adjuvant treatment of acute lung injury can significantly improve patient condition and reduce inflammatory reaction. It is worth popularizing clinically.

关 键 词：急性肺损伤 乌司他丁 丹参注射液 

分 类 号：R563[医药卫生—呼吸系统]