明胶空心胶囊中残留氯乙醇和环氧乙烷的测定方法改进  

Improvement in determination of residual chlorine ethylene oxide and ethanol in gelatin hollow capsules

作　　者：吴美香 欧阳吉德 

机构地区：[1]郴州市食品药品检验所,423000

出　　处：《国际医药卫生导报》2013年第3期404-407,共4页International Medicine and Health Guidance News

摘　　要：目的改进明胶空心胶囊中残留氯乙醇和环氧乙烷的测定方法。方法采用大口径毛细管柱代替标准方法中规定的10％聚乙二醇填充柱，检测器采用FID和TCD，分别进行测定。结果对氯乙醇和环氧乙烷的测定中，采用大口径毛细管柱分离效果优于固定液为10％聚乙二醇填充柱；检测器采用FID优于ECD。结论该方法重现性佳，分离效果好。Objective To improve the method for detecting residual chlorine ethylene oxide and ethanol in gelatin hollow capsules. Methods The 10% polyethylene glycol packed column was replaced by a large cal- iber capillary column. Detection was conducted with FID and TCD as detectors. Results The large caliber capillary column was superior to the packed column with stationary liquid of 10% polyethylene glycol in the separation effect. FID was better than ECD for detection. Conclusions This new method has better repeatability and separation effect.

关 键 词：氯乙醇 环氧乙烷 大口径毛细管柱 

分 类 号：TQ46[化学工程—制药化工]