股动脉注射琥珀胆碱诱发肌梭传入对膈神经放电的影响  

Effects of muscle spindle afferents invoked by intraarterial injectio n of succinylcholine on the phrenic nerve discharges

作　　者：邢国刚[1] 樊小力[1] 宋新爱[1] 

机构地区：[1]西安交通大学医学院生理学教研室,西安710061

出　　处：《西安医科大学学报》2000年第5期411-414,共4页Journal of Xi'an Medical University(Chinese)

基　　金：陕西省卫生厅资助课题

摘　　要：目的 观察肌梭传入活动是否对呼吸运动具有反射性调节作用。方法 实验用63只麻醉、制动、切断双侧颈迷走神经、肌松、人工呼吸的家兔，以膈神经放电作为呼吸观测指标，观察股动脉注射琥珀胆碱(Succinylcholine,Sch)诱发肌梭传入活动对呼吸的影响。结果 ①产生易化作用的有40例(63..49%)，其中23例(36..51%)呈吸气延长效应；17例(26..98%)呈抑呼增频效应。产生抑制效应的有11例(17..46%)，呈双相反应的4例(6..35%)，8例(12..70%)无明显作用。②吸气延长效应主要表现为吸气时程(Ti)延长，呼吸时程(Te)有缩短趋势，但差异无显著性，Ti/Te比值增加，呼吸频率(RF)变化不明显；抑呼增频效应主要表现为Te缩短，Ti变化不明显，Ti/Te比值增加，RF加快。③肌注布比卡因破坏肌梭后，同剂量的Sch使上述呼吸易化效应明显减弱。结论 股动脉注射Sch诱发的肌梭传入活动对呼吸运动具有明显的增强作用。Objective\ To study wether muscle spindle affer ents hav e the regulating effects on respiratory movement.Methods\ Experiment s were performed on 36 anesthetized,immobilized,bilaterally vagotomized and art i ficially ventilated rabbits.Using the phrenic nerve discharge as the respiratory index,this experiment have assessed the effects of muscle spindle afferents inv oked by intraarterial injection of succinylcholine(Sch) on respiration.Res ults\ ①In 40(63.49%) cases which had the facilitated effects,23(36.51%) c ases had the effect of prolonged inspiratory phase and 17(26.98%) cases had the effect of attenuated expiratory phase and augmented respiratory frequenc y.In addition,there were 11(17.46%) cases which had the attenuated effects,and 4 (6.35%) cases which had the biphasic effects,and 8(12.7%) cases which had no eff ects;②The effect of prolonged inspiratory phase mainly showed the prolongation of inspiratory duration(Ti),but the effect of attenuated expiratory phase and au gmented respiratory frequency mainly showed the decrease of expiratory duration (Te) and the augmentation of respiratory frequency(RF);③The above facilitated e ffects of Sch were significantly attenuated by intramuscular application of bupi vacaine to destroy the muscle spindles.Conclusion\ These results sug gest that muscle spindle afferents induced by intraarterial injection Sch have a significant facilitated effect on respiration.\=

关 键 词：琥珀胆碱 肌梭 膈神经放电 呼吸调节 

分 类 号：R332.3[医药卫生—人体生理学] R338.8[医药卫生—基础医学]