胰岛素样生长因子结合蛋白-3与胎儿宫内生长迟缓的关系  

A study on the relationship between IGFBP3 and intrauterine g rowth retarded

作　　者：张培莲[1] 李桂林[2] 殴阳克勇 周雪芹 

机构地区：[1]西安市第一医院妇产科,西安710002 [2]西安交通大学第一医院妇产科

出　　处：《西安医科大学学报》2000年第5期468-470,共3页Journal of Xi'an Medical University(Chinese)

摘　　要：目的 探讨胰岛素样生长因子结合蛋白3(IGFBP3)与胎儿宫内生长的关系，及其在胎儿宫内生长迟缓(IUGR)发病中的作用，从而对IUGR的病因作进一步的探讨。方法 选取20例分娩IUGR儿、10例分娩巨大儿及20例正常产妇，分娩后抽取母静脉血及脐静脉血，分离血清(各组产妇均无产科及内外科合并症)。用免疫放射法测定血清中IGFBP-3的浓度。结果 ①母血IGFBP-3浓度显著高于脐血(P＜0..01)，且二者之间无相关关系(r=-0.18,P＞0.05)。②脐血中IGFBP-3浓度在IUGR组显著低于对照组(P＜0..01)，但巨大儿组与对照组之间无显著差别(P＞0..05)，脐血IGFBP-3的浓度与新生儿出生体重及胎盘重量呈正相关关系(r=0.63,r=0.48,P均＜0..01)。③各组母血中IGFBP-3浓度无明显差别(P＞0..05)。结论 ①母血及脐血IGFBP-3的来源不同，母血中的IGFBP-3不能通过胎盘屏障。②胎儿自身分泌的IGFBP-3与胎儿生长关系密切，其浓度降低可能是导致IUGR的重要原因之一。Objective To explore the effect of insulinlike grow th factorbinding protein3 (IGFBP3) in the intrauterine growth retarded (IU GR).Methods Samples of maternal blood and matched umbilical cor d blood were collected at time of delivery from 20 normally grown (control group ) and 20 intrauterine growth retarded (IUGR group) and 10 fetal macrosonia (macr osonia group).IGFBP3 of serum was mesured with IRMA.Results ①IGFBP3 in maternal serum was significantly higher than that of in umbilical serum (P＜0.01) and there was no correlation between them (r=- 0.18,P＞0.05);②The IGFBP3 level of umbilical serum in IUGR group was si g nificantly lower than that of in control group (P＜0.01) ,and was po sitively correlated with birth weight and weight of placenta (r=0.63 and r=0.48,P＜0.01);③There was no difference of the IGFBP3 l evel in maternal serum among three groups;④The IGFBP3 level of umbilical seru m in macrosonia group was not different from those in control group.Conc lusions ①IGFBP3 in maternal serum can't pass through the placenta;② I GFBP3 of fetal origin may have the close relationship with the fetal developme nt.The decrease of IGFBP3 may be one of the reasons of IUGR.

关 键 词：胎儿 宫内生长迟缓 免疫放射法 IGFBP-3 

分 类 号：R714.430.2[医药卫生—妇产科学]