区域动脉灌注5-Fu和抗生素降低急性坏死性胰腺炎感染及死亡率  

REGIONAL ARTERIAL INFUSION OF 5-Fu AND IMIPENEM DECREASES INFECTION AND MORTALITY OF ACUTE SEVERE PANCREATITIS

作　　者：孙立波[1] 张德恒[1] 田力[1] 郑泽霖[1] 

机构地区：[1]白求恩医科大学三院普外科,长春130031

出　　处：《中国普外基础与临床杂志》2000年第6期373-374,共2页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　探讨 5 Fu合并抗生素泰能区域动脉灌注 (regionalarterialinfusion ,RAI)能否降低急性坏死性胰腺炎 (ANP)感染和死亡率。方法　选择ANP 5 3例 ,分为A、B、C组。A组 16例 ,静脉途径给予 5 Fu及泰能 ;B组 2 2例 ,RAI途径给予 5 Fu ,静脉给予泰能 ;C组 15例 ,RAI途径交替使用 5 Fu和泰能。结果　C组感染率 (0 )明显低于A组(5 0 .0 % )和B组 (2 7.3 % ) ,P <0 .0 0 1,P <0 .0 1;B、C两组死亡率分别为 18.2 %和 13 .3 % ,均明显低于A组 (43 .8% ) ,P <0 .0 5。结论　RAI途径应用 5 Fu合并泰能能有效降低ANP感染及死亡率。Objective To determine whether regional arterial infusion (RAI) of 5-Fu and imipenem could decrease infection and mortality of acute necrotic pancreatitis (ANP) or not. Methods Fifty three patients with ANP were devided into three groups, group A, 16 patients who received intravenous 5-Fu and imipenem, group B, 22 patients who received 5-Fu by RAI and imipenem intravenously, and group C, 15 patients who received both 5-Fu and imipenem by RAI. Results The incidence of infection of ANP in group C (0%) was significantly lower than that in group A (50.0%) and B (27.2%), and the mortality rates in group B (18.1%) and C (13.3%) were significantly reduced as compared with group C (43.8%). Conclusion RAI of 5-Fu and imipenem was effective in reducing ANP infection and mortality rates.

关 键 词：急性坏死性胰腺炎 抗生素 胰酶抑制剂 区域性动脉灌注 

分 类 号：R657.510.5[医药卫生—外科学]