Regulatory B cells in autoimmune diseases  

作　　者：Min Yang Ke Rui Shengjun Wang Liwei Lu 

机构地区：[1]Department of Pathology and Center for Infection and Immunology, The University of Hong Kong, Hong Kong, China [2]Department of Immunology, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, China [3]These authors contributed equally to this work.

出　　处：《Cellular & Molecular Immunology》2013年第2期122-132,共11页中国免疫学杂志（英文版）

摘　　要：B cells are generally considered to be positive regulators of the immune response because of their capability to produce antibodies, including autoantibodies. The production of antibodies facilitates optimal CD4＋ T-cell activation because B cells serve as antigen-presenting cells and exert other modulatory functions in immune responses. However, certain B cells can also negatively regulate the immune response by producing regulatory cytokines and directly interacting with pathogenic T cells via cell-to-cell contact. These types of B Cells are defined as regulatory B （Breg） cells. The regulatory function of Breg cells has been demonstrated in mouse models of inflammation, cancer, transplantation, and particularly in autoimmunity. In this review, we focus on the recent advances that lead to the understanding of the development and function of Breg cells and the implications of B cells in human autoimmune diseases.B cells are generally considered to be positive regulators of the immune response because of their capability to produce antibodies, including autoantibodies. The production of antibodies facilitates optimal CD4＋ T-cell activation because B cells serve as antigen-presenting cells and exert other modulatory functions in immune responses. However, certain B cells can also negatively regulate the immune response by producing regulatory cytokines and directly interacting with pathogenic T cells via cell-to-cell contact. These types of B Cells are defined as regulatory B （Breg） cells. The regulatory function of Breg cells has been demonstrated in mouse models of inflammation, cancer, transplantation, and particularly in autoimmunity. In this review, we focus on the recent advances that lead to the understanding of the development and function of Breg cells and the implications of B cells in human autoimmune diseases.

关 键 词：autoimmune disease interleukin-lO regulatory B cells 

分 类 号：Q2[生物学—细胞生物学] TP212.3[自动化与计算机技术—检测技术与自动化装置]