抑郁症的ERPs电流源模型与特征分析  

Brain Electrical Source Analysis of Event-Related Potentials in Depressive Disorder

作　　者：李岳峙[1] 胡勇[2] 王悟夷[3] 

机构地区：[1]深圳大学机电与控制工程学院,深圳518060 [2]香港大学李嘉诚医学院 [3]天津大学精密仪器与光电子工程学院,深圳300072

出　　处：《中国生物医学工程学报》2013年第1期28-37,共10页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金(30970779);广东省自然科学基金(9151806001000009;s2011040004584)

摘　　要：采用3-刺激视觉oddball实验范式,研究干扰子刺激和靶刺激条件下抑郁症患者的大脑电流源的异常电流响应过程。分别采集了抑郁症和健康受试者的64导联脑电,以该实验任务的功能磁共振激活簇空间坐标为约束条件,建立了干扰子刺激和靶刺激条件下事件相关电位的脑区域源模型,通过脑源重建法计算得到14个区域源的源电流波形,经非配对t检验和置换检验后发现:在靶刺激条件下,抑郁症患者的右侧脑岛、右侧中央前沟在P300晚期产生的源电流幅度与正常人有显著差异(P<0.05),它引起右侧头皮前额区的异常负电位。在干扰子刺激条件下,患者的左侧中央前沟在P300晚期产生的源电流与正常人有明显差异,差异显著性具有趋势意义(P=0.087),它引起左侧前额区的异常近零电位。结果表明:通过源电流计算发现了抑郁症患者的中央前沟和脑岛的P300活动发生显著异常。Using visual three-stimulus oddball paradigm, activities of cortical current sources elicited by target and distractor stimuli were investigated in depressive patients. The 64 - channel EEG signals were recorded in healthy subjects and depressed patients during the task. A regional source model with constraints of spatial coordinates from fMRI BOLD clusters was applied to event-related potentials （ERPs） data in the target and distractor conditions. The reconstructed source activities were sent to unpaired t-test and permutation test, statistical results indicated source activities in the right insular and right precentral sulcus in the late phase of P300 show significant difference between patients and healthy controls in the target condition, and scalp voltage maps projected by the current flow direction of corresponding regional sources in patients show abnormal negative potential over the right prefrontal scalp area. It was also found that source activity in the left precentral sulcus in the late phase of P300 showed significant difference at a trend level （P = 0. 087） in the distractor condition. Scalp voltage map showed abnormal near-zero potential over the left prefrontal area.

关 键 词：脑电 区域源模型 抑郁症 

分 类 号：R318[医药卫生—生物医学工程]